Abstract
HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral antigen and autoantigen to T cells. Researches reported single nucleotide polymorphism (SNP) of HLA-DP associated with HBV infection and autoimmune diseases such as SLE. However, little is known about the relationship between HLA-DP and rheumatoid arthritis (RA). Rs9277535 is located in 3' UTR region of HLA-DPB1, a subunit of HLA-DP, and was reported to affect HLA-DP mRNA expression. In the present study, we explored the relationship between gene polymorphism of rs9277535 in HLA-DPB1 and RA susceptibility and progression. Samples from 254 patients with RA and 391 age- and sex-matched healthy controls were collected and genotyped by a polymerase chain reaction-high-resolution melting (PCR-HRM) assay. Serological tests (anti-CCP, rheumatoid factor, C-reactive protein, anti-keratin antibody) were detected by laboratory assays. Strong association was observed between SNP rs9277535 in HLA-DP and RA susceptibility (allele frequency distribution: OR = 1.409, 95%CI = 1.121-1.773, P = 0.004). Further validation was provided by dis...Continue Reading
References
Jan 27, 1998·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C SeidlJ P Kaltwasser
Nov 10, 2005·Arthritis Research & Therapy·Thomas Skogh
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Zoltán SzekaneczGabriella Lakos
Apr 5, 2008·Current Opinion in Rheumatology·Lars KlareskogJohan Rönnelid
May 21, 2008·Annals of the Rheumatic Diseases·G WellsP L C M van Riel
Dec 17, 2008·Annals of the New York Academy of Sciences·Walther J van VenrooijGer J M Pruijn
Apr 8, 2009·Nature Genetics·Yoichiro KamataniKoichi Matsuda
May 12, 2009·Autoimmunity Reviews·Péter SzodorayZoltán Szekanecz
Jan 19, 2010·Journal of Autoimmunity·Gabriel J TobónAlain Saraux
Apr 13, 2010·Expert Review of Clinical Immunology·Gisela Orozco, Anne Barton
Jun 30, 2010·Rheumatology·Robby EngelmannBrigitte Mueller-Hilke
Aug 12, 2010·Annals of the Rheumatic Diseases·Daniel AletahaGillian Hawker
Nov 5, 2010·PloS One·Judith FieldJim Stankovich
Feb 25, 2011·Genes and Immunity·T R O'BrienL Prokunina-Olsson
Sep 17, 2011·Rheumatology International·Luis Rodríguez-RodríguezBenjamín Fernández-Gutiérrez
Jan 16, 2013·PloS One·Hiroshi FurukawaShigeto Tohma
Feb 6, 2013·Nature Reviews. Rheumatology·Sebastien ViatteSoumya Raychaudhuri
Mar 30, 2013·Journal of Immunoassay & Immunochemistry·Yongmei ZhouJinwang Xiong
Jan 28, 2014·Molecular Immunology·Nina LauterbachMarcel G J Tilanus
May 13, 2014·Annals of the Rheumatic Diseases·A Jimmy YtterbergAnca I Catrina
Jul 22, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Yun LiaoLanlan Wang
Aug 12, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Tetsuya HosakaHiromitsu Kumada
Aug 21, 2014·Arthritis Research & Therapy·Omri SnirLeonid Padyukov
Sep 23, 2014·Rheumatology·Annie YarwoodJane Worthington
Apr 29, 2015·JAMA : the Journal of the American Medical Association·Sebastien ViatteAnne Barton
Aug 5, 2015·PloS One·Lin ChenLanlan Wang
Dec 1, 2015·International Journal of Immunogenetics·J WangY Quan
Jul 10, 2016·International Immunopharmacology·Xinle LiuLanlan Wang
Jan 18, 2017·Scientific Reports·Junlong ZhangLanlan Wang
Citations
Sep 21, 2018·PloS One·Hiroshi FurukawaShigeto Tohma
Dec 1, 2019·Molecular Genetics & Genomic Medicine·Zhendong WangLi Wang
Nov 20, 2019·HLA : Immune Response Genetics·L Burmistrova AlexandraA Suslova Tatiana
Nov 12, 2019·Frontiers in Cellular and Infection Microbiology·Yang SunLianbo Xiao
Feb 6, 2021·Rheumatology International·Burak InceAhmet Gül
Jun 7, 2020·Experimental Eye Research·D P C VergouwenM W J Schreurs
May 1, 2021·Immunological Investigations·Xin WanYue Hu
Apr 21, 2021·Aging·Zhicheng YangRuiping Liu
Jul 3, 2021·International Journal of Molecular Sciences·Camille JacquesBéatrice Lejeune