Genetic polymorphism of XRCC1 Arg399Gln is associated with survival in non-small-cell lung cancer patients treated with gemcitabine/platinum

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Wei-Yu LiaoChong-Jen Yu

Abstract

Elevated DNA-repair capacity has been related to chemoresistance of platinum doublet chemotherapy in non-small-cell lung cancer (NSCLC). We evaluated whether single nucleotide polymorphisms of DN- repair genes excision repair cross-complementing group 1 (ERCC1), ERCC2, x-ray repair cross-complementing group 1 (XRCC1), XRCC3, and RRM1 associate with treatment outcome in NSCLC patients receiving gemcitabine plus platinum as their first-line chemotherapy. Genotyping for eight polymorphisms in five DNA-repair genes was performed with the GenomeLab nucleotide polymorphismstream Genotyping System in 62 advanced NSCLC patients in a training set and 45 patients in a validation set treated with gemcitabine/platinum. In the training set, the wild-type genotype of XRCC1 Arg399Gln (G/G) was associated with decreased median overall survival (OS) (22 months, 95% confidence interval [CI], 10-34 months versus not reached, log-rank test, p = 0.005) than those carrying variant genotypes (G/A+A/A). In addition, there was a statistically significant longer median OS in patients carrying wild-type ERCC2 Asp312Asn genotype (G/G) (51 months, 95% CI, 19-82 months versus 10 months, log-rank test, p < 0.001) than those carrying heterozygous variant geno...Continue Reading

References

Nov 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rafael RosellNoemi Reguart
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Feb 26, 2004·Seminars in Oncology·Rafael RosellRosario García-Campelo
May 14, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeong-Seon RyuTae-Sook Hwang
Jun 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarada GurubhagavatulaDavid C Christiani
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei ZhouDavid C Christiani
Dec 24, 2004·American Journal of Epidemiology·Simone Benhamou, Alain Sarasin
Sep 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F M WachtersH J M Groen
Jan 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R de las PeñasR Rosell
Aug 3, 2006·International Journal of Occupational Medicine and Environmental Health·Yongliang LiPaul W Brandt-Rauf
Sep 8, 2006·The New England Journal of Medicine·Ken A OlaussenUNKNOWN IALT Bio Investigators
Sep 19, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P CeppiG V Scagliotti
Sep 20, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chikako KiyoharaYoichi Nakanishi
Oct 13, 2006·Chest·Julian R MolinaJames R Jett
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela F GiachinoGiorgio V Scagliotti
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmelo TibaldiRomano Danesi
Jun 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Karen Kelly, Chao Huang
Jan 23, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xinchen SunZhou Yingfeng
Jun 12, 2009·Drug Metabolism Reviews·Andrea WongFederico Innocenti
Jan 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·John GoffinUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
Feb 23, 2010·Trends in Biochemical Sciences·David M Wilson, Michael M Seidman
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ming YinQingyi Wei
Dec 18, 2010·The Lancet Oncology·Lars Petter JordheimCharles Dumontet
Jan 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne M HorganGeoffrey Liu

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Citations

Feb 28, 2013·International Journal of Molecular Sciences·Kayo OsawaYoshiaki Kido
Jan 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruotian WangXiuyi Zhi
Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanlong Yang, Lei Xian
Jan 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiuguang QinXiaomeng Gu
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Gang KeZhen-Ya Shen
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Da-Qing ChenShu-Juan Yang
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jin MiaoLi Kai
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sheng YeShen-Ming Wang
Apr 15, 2014·Biochimica Et Biophysica Acta·Elaina N MaginnEuan A Stronach
Jul 26, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Helen Naemi HonmaLair Zambon
Nov 24, 2018·Journal of Clinical Pathology·Milena CavicRadmila Jankovic
Jun 15, 2021·Neoplasia : an International Journal for Oncology Research·Ling TianGuo Chen

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