Genetic polymorphisms and forensic efficiency of 19 X-chromosomal STR loci for Xinjiang Mongolian population

PeerJ
Ling ChenBo-Feng Zhu

Abstract

X-chromosomal short tandem repeat (X-STR) loci are playing an increasingly important role in some complex kinship cases in recent years. To investigate the forensic efficiency of X-STRs of Mongolian minority group from Xinjiang Uygur Autonomous Region, China, and further depict the genetic relationship among Xinjiang Mongolians and other populations, 267 blood samples from unrelated healthy Xinjiang Mongolians were amplified by an AGCU X-19 STR kit. No deviations for all 19 X-STR loci were observed from the Hardy-Weinberg equilibrium after Bonferroni correction (p > 0.0026) in female samples. The most frequent allele was allele 10 at locus DXS10164 with the frequency 0.5663. The polymorphism information content values of the 19 X-STR loci were more than 0.5 with the highest polymorphism at the locus DXS10135. The cumulative power of discrimination were 0.99999999999999999999988761005481 in females and 0.999999999999903 in males, respectively; and the cumulative mean exclusion chances were 0.9999999969738068321121 in duos and 0.999999999998952 in trios, respectively. The seven linkage groups were extremely informative, with all the haplotype diversities greater than 0.9487. No linkage disequilibrium was observed for a significan...Continue Reading

References

Jan 1, 1983·Journal of Molecular Evolution·M NeiY Tateno
Mar 23, 2002·Forensic Science International : Synergy·Jeanett EdelmannReinhard Szibor
Apr 12, 2003·International Journal of Legal Medicine·R SziborD Krause
Dec 3, 2003·Forensic Science International : Synergy·Reinhard SziborMatthias Michael
Aug 1, 2006·Forensic Science International : Synergy·Peter M Schneider
Jun 19, 2007·Genomics, Proteomics & Bioinformatics·Qiao-Fang HouSheng-Bin Li
Jun 1, 2007·Forensic Science International. Genetics·Reinhard Szibor
Jul 1, 2011·International Journal of Legal Medicine·Serena PasinoCarlo Robino
Dec 23, 2011·Molecular Biology Reports·Suhua ZhangChengtao Li
May 16, 2012·International Journal of Legal Medicine·Michinaga SamejimaKiyoshi Minaguchi
Jan 1, 2013·Molecular Biology Reports·Seisaku UchigasakiDaisuke Takahashi
Feb 5, 2013·Forensic Science International. Genetics·Angel CarracedoPeter M Schneider
Feb 8, 2014·Forensic Science International. Genetics·Angel CarracedoPeter M Schneider
Apr 12, 2014·Electrophoresis·Hao-Tian MengXing Wei
Dec 3, 2014·Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·Qiansu YeMeisen Shi
May 5, 2016·Journal of Zhejiang University. Science. B·Yu-Xin GuoBo-Feng Zhu
Apr 27, 2017·Molecular Biology and Evolution·Kazuhiro NakayamaSadahiko Iwamoto

❮ Previous
Next ❯

Citations

Jan 31, 2020·Molecular Genetics & Genomic Medicine·Zhen DangYequan Wang
Oct 14, 2020·Medicine, Science, and the Law·Supakit Khacha-Ananda, Phatcharin Mahawong

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
MDS

Software Mentioned

Poptree2
PowerStats
SPSS
R
Genepop

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.