Genetic polymorphisms associated with the inflammatory response in bacterial meningitis

BMC Medical Genetics
Fabrícia Lima FontesLucymara Fassarella Agnez-Lima

Abstract

Bacterial meningitis (BM) is an infectious disease that results in high mortality and morbidity. Despite efficacious antibiotic therapy, neurological sequelae are often observed in patients after disease. Currently, the main challenge in BM treatment is to develop adjuvant therapies that reduce the occurrence of sequelae. In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM. In this study, we analyzed the associations between the SNPs TNF -308G > A, TNF -857C > T, IL-8 -251A > T and BM and investigated gene-gene interactions, including the SNPs that we published previously. The study was conducted with 54 BM patients and 110 healthy volunteers (as the control group). The genotypes were investigated via primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR) or polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis. Allelic and genotypic frequencies were also associated with cytokine and chemokine levels, as measured with the x-MAP method, and cell counts. We analyzed gene-gene interactions among SNPs using the generalized multif...Continue Reading

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Citations

Nov 30, 2019·Frontiers in Immunology·Fanni A Boros, László Vécsei
Apr 9, 2021·Pharmacology & Therapeutics·Marta Marszalek-GrabskaWaldemar A Turski
Jun 14, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Vítor Chehuen BicalhoJorge Marcondes de Souza
Jun 13, 2021·Acta Tropica·Débora de Almeida AloiseValter Ferreira de Andrade-Neto

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Methods Mentioned

BETA
genotyping
PCR
gene knockout
acetylation

Software Mentioned

Plex manager
Haploview
Bio
STATA
GENEPOP
GMDR Beta
GraphPad Prism5

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