Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi'an city in China.

Croatian Medical Journal
Chunmei ShenShengbin Li

Abstract

To determine genetic polymorphisms at human leukocyte antigen (HLA)-A, -B, and -DRB1 loci in Han population of Xi'an city in China. Polymerase chain reaction-based reverse line-strip sequence specific oligonucleotide hybridization was used to determine the alleles of HLA-A, -B, and -DRB1 in 516 unrelated, healthy individuals of Han population in Xi'an. Allele frequencies at HLA-A, -B, and -DRB1 loci were estimated by direct counting method. Haplotype frequencies were calculated from genotype data by expectation maximization. A total of 14 alleles of HLA-A, 33 alleles of HLA-B, and 13 alleles of HLA-DRB1 were found. The most common alleles were HLA-A*02 (28.39%), A*11 (19.19%), and A*24 (16.28%); HLA-B*13 (11.05%), B*15 (B62: 9.30%), and B*51 (8.53%); and HLA-DRB1*15 (17.15%), DRB1*09 (13.18%), and DRB1*04 (10.85%). The most common haplotypes of HLA-A-B-DRB1 haplotype were HLA-A*30-B*13-DRB1*07 (3.93%), HLA-A*02-B*46-DRB1*09 (3.20%), and HLA-A*33-B*58-DRB1*17 (1.63%). The finding that the HLA loci are highly polymorphic in Han population of Xi'an City may be useful for population genetics, HLA-related studies, human identification, and paternity tests in forensic sciences.

Citations

Apr 30, 2017·The British Journal of Ophthalmology·Jun Hong JiangYuan Bo Liang
Apr 28, 2009·Transfusion Medicine·D TeoS Lam
Jul 25, 2009·Tropical Medicine & International Health : TM & IH·V J LeeY S Leo
Jun 27, 2018·BMC Bioinformatics·Maria Luisa Matey-HernandezJose M G Izarzugaza
Jan 27, 2017·Translational Neuroscience·Ting-Ting YangGuang-Zhi Liu

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