Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury

Hepatology Communications
Herbert L BonkovskyUS DILIN Investigators

Abstract

With the application of genetic testing to contemporary medical diagnostics and practice, it has become apparent that the phenotypes of many disorders are modulated by host genetic factors. The aim of the current study was to determine whether selected single nucleotide polymorphisms (SNPs) unrelated to the human leukocyte antigen region or other immune pathways, including those associated with nonalcoholic fatty liver disease (NAFLD), may influence development, severity, or outcomes of drug-induced liver injury (DILI). Thirteen variants previously associated with NAFLD and/or selected other liver diseases were tested in 832 Caucasian DILI cases and 10,397 Caucasian population controls. DILI cases were attributed to multiple agents (177 individual drugs), with 56 cases due to herbal/dietary supplement products. Allele frequencies were imputed from recent genome-wide association studies and compared to those for European control samples from the Gnomad database. Significance was tested by linear regression or logistic regression, depending on the nature of the trait. Any variant that passed the Bonferroni threshold of P < 0.0004 ( 0.05 13 ) was considered a significant association. None of the variants proved to be signifi...Continue Reading

References

Aug 23, 2016·World Journal of Gastroenterology : WJG·Tyler J SeversonHerbert L Bonkovsky
Jan 22, 2019·Gastroenterology·Elizabeth T CirulliUNKNOWN International DILI consortium (iDILIC)

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Citations

Jul 30, 2020·Minerva gastroenterologica e dietologica·György M Buzás
Aug 28, 2020·Archives of Toxicology·Miren Garcia-CortesRaúl J Andrade
Nov 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Camilla StephensRaúl J Andrade

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