Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia

Acta Neurologica Scandinavica
G ZulianiR Fellin

Abstract

Paraoxonase, angiotensin-converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR), and apo E gene polymorphisms were evaluated in older patients with vascular dementia (VD) or late-onset Alzheimer's disease (LOAD). Sixty patients with VD, 45 patients with LOAD, and 54 non-demented controls were compared. No differences in the distribution of paraoxonase, ACE, and MTHFR polymorphisms were found. The overall frequency of apo E epsilon4 allele was "low"; epsilon4 allele was more frequent in LOAD (17.5%) and VD (13.3%) compared with controls (9.2%), but the difference was not statistically significant. Paraoxonase, ACE, and MTHFR polymorphisms were not associated with VD or LOAD; these common polymorphisms might have a marginal role in the pathogenesis of dementia in older subjects. In spite of a "low" frequency of the apo E epsilon4 allele in our sample, the frequency of epsilon4 allele was about double in LOAD compared with controls.

References

Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Jan 1, 1993·Nature Genetics·R HumbertC E Furlong
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R W JamesD Pometta
Jan 21, 1993·The New England Journal of Medicine·I SkoogA Svanborg
Jan 15, 1993·The American Journal of Cardiology·J E EichnerJ D Neaton
Aug 1, 1995·Aging : Clinical and Experimental Research·G RuiuG Pagano
Mar 12, 1997·JAMA : the Journal of the American Medical Association·D A SnowdonW R Markesbery
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·D K SangheraM I Kamboh
Apr 18, 1998·Human Molecular Genetics·J C LambertM C Chartier-Harlin
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·J ChapmanN M Bornstein
Sep 16, 1998·Human Genetics·O Fletcher, A M Kessling
Nov 11, 1998·Journal of the American Geriatrics Society·D L Nyenhuis, P B Gorelick
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·J GusseklooR G Westendorp
Nov 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R AlvarezE Coto
Feb 19, 2000·Archives of Neurology·L A FarrerE I Rogaev

❮ Previous
Next ❯

Citations

Nov 6, 2002·Journal of the Neurological Sciences·A FrankP Barreiro
Dec 14, 2002·Annals of the New York Academy of Sciences·Yosuke WakutaniKenji Nakashima
Dec 14, 2002·Annals of the New York Academy of Sciences·Thierry F DantoineJean-Pierre Charmes
Jul 16, 2011·Dementia and Geriatric Cognitive Disorders·A Klimkowicz-MrowiecA Slowik
Oct 15, 2009·Neuromolecular Medicine·Carmen MartínezFélix Javier Jiménez-Jiménez
Jun 15, 2011·The International Journal of Neuroscience·Ye HuaMin Ye
Mar 4, 2009·Critical Reviews in Clinical Laboratory Sciences·Jordi CampsJorge Joven
Nov 28, 2002·Annals of Medicine·Ramón Cacabelos
Nov 15, 2013·Redox Report : Communications in Free Radical Research·Teresita Menini, Alejandro Gugliucci
Dec 17, 2008·Journal of Geriatric Psychiatry and Neurology·Hua LiuYi Wang
Jan 16, 2007·Arquivos de neuro-psiquiatria·Vanessa Cavalcante da SilvaMaria Tereza Cartaxo Muniz
Oct 7, 2004·Neurobiology of Aging·Robert StewartAnthony Mann
Oct 30, 2009·The European Journal of Neuroscience·Valérie LeducJudes Poirier
Sep 29, 2017·Journal of Geriatric Psychiatry and Neurology·Yi NieHua Liu
Jun 26, 2002·European Journal of Human Genetics : EJHG·Massimiliano BonafèClaudio Franceschi
Sep 27, 2002·International Journal of Geriatric Psychiatry·Karin NilssonBjörn Hultberg
Jun 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Patrick G Kehoe
Oct 13, 2007·International Journal of Geriatric Psychiatry·Jae-Min KimJin-Sang Yoon
Jul 22, 2005·American Journal of Epidemiology·Donald J LehmannPatrick G Kehoe
Dec 2, 2005·Human Molecular Genetics·Porat M ErlichUNKNOWN MIRAGE Study Group
Apr 1, 2016·Journal of Alzheimer's Disease : JAD·Qingting HuNaidong Wang
Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Jia-Hao SunJin-Tai Yu
Feb 25, 2020·Current Alzheimer Research·Marta KowalskaJolanta Dorszewska
Feb 10, 2016·Clinical and Experimental Pharmacology & Physiology·Vivek SrinivasanDaniel K Y Chan
Mar 7, 2017·BMC Medicine·M Arfan IkramHieab H H Adams
May 23, 2020·Neurobiology of Disease·Rita GuerreiroJose Bras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.