Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinoma

Cancer
Zefang RenWei Zheng

Abstract

In addition to possessing many physiologic functions, human growth hormone-1 (GH1) has been shown in recent in vitro and in vivo experiments to induce malignant disease, including breast carcinoma. The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the Shanghai Breast Cancer Study. Included in the current investigation were 1193 women with breast carcinoma (case patients) and 1310 healthy women from the same community (control patients) who completed in-person interviews and provided blood samples. Genetic polymorphisms in the proximal promoter region (nucleotide [nt] -162 to nt +148 relative to the transcription start site of the GH1 gene) were searched and confirmed by resequencing DNA samples from 43 study participants. A novel polymorphism, a transition from adenine to guanine at nt 69 (A69G), was identified. Samples from all participants were genotyped with TaqMan 5' nuclease assays for five common single-nucleotide polymorphisms (SNPs)-four in the proximal region (A-75G, G-57T, A-6G, and A69G) and one in intron 4 (T1169A). The frequencies of occurrence for the minor alleles in these polymorphic sites were 0.04, 0.60, 0.24, 0.03, and 0.34, respectively, in the control...Continue Reading

References

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Citations

Nov 4, 2006·Breast Cancer Research and Treatment·Kerstin WagnerAsta Försti
Feb 16, 2012·Nutrition and Cancer·Lu-Ying TangZe-Fang Ren
Jan 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing ShiShuang Cai
Aug 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Chang-Ming GaoKazuo Tajima
Jan 17, 2007·Clinical Endocrinology·Cristina EstebanDiego Yeste
Nov 15, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jo K PerryPeter E Lobie
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Mara GiordanoPatricia Momigliano-Richiardi
Dec 1, 2018·Endocrine Reviews·Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski
Sep 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Alexis D GuedesIeda T N Verreschi

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