Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism

Human Immunology
C G ParksGlinda S Cooper

Abstract

Tumor necrosis factor (TNF) is involved in the pathogenesis of systemic lupus erythematosus (SLE), but the role of TNF polymorphisms in SLE susceptibility remains unclear. Previous studies in different populations report an inconsistent association of the TNF-alpha -308A allele with SLE, sometimes depending on the presence of HLA-DR3. We examined the association of polymorphisms in TNF-alpha (-308G/A, -238G/A) and TNFbeta (+252A/G) in a population-based study of SLE in the southeastern United States and considered TNF-SLE associations with respect to HLA-DR3 and DR2 and the interleukin (IL)-1alpha -889C/T polymorphism, previously linked to SLE in this population. Genotypes were analyzed for 230 recently diagnosed SLE patients who met American College of Rheumatology classification criteria and 276 age- and sex-matched controls, randomly selected from driver's license registries. Carriage of the TNF-alpha -308A allele was significantly associated with SLE in Caucasians (OR = 2.3; 95% CI 1.4, 3.9), but not African Americans. Analyses stratified by IL-1alpha -889 genotypes (C/C vs C/T or T/T) revealed independent associations of SLE with TNF-alpha -308A or HLA-DR2 and DR3. This reflected a significant interaction of TNF and IL-1 g...Continue Reading

References

Aug 1, 1995·Annals of the Rheumatic Diseases·M RudwaleitP Wordsworth
Jan 1, 1994·European Journal of Immunology·A G WilsonG W Duff
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanV J Canzanello
Jul 1, 1996·Kidney International·S LemayA K Singh
Aug 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·C M Milner, R D Campbell
Mar 14, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Violeta RusCharles S Via
Jul 11, 2002·Annals of Medicine·Jason H Moore, Scott M Williams
Aug 16, 2002·American Journal of Epidemiology·Julian LittleClarice Weinberg
Sep 11, 2002·Cytokine & Growth Factor Reviews·Toshitkatsu Hanada, Akihiko Yoshimura
Dec 21, 2002·Scandinavian Journal of Rheumatology·J AittoniemiJ Antonen
May 8, 2003·American Journal of Physiology. Cell Physiology·Baiteng ZhaoPhillip D Bowman

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Citations

Mar 25, 2010·Rheumatology International·Yan-Feng ZouDong-Qing Ye
May 6, 2011·Rheumatology International·Maria José SantosJoão Eurico Fonseca
Jan 19, 2006·European Journal of Human Genetics : EJHG·Young Ho LeeSwapan K Nath
Apr 6, 2006·Omics : a Journal of Integrative Biology·Stewart ChoHilmi Ozcelik
Jan 11, 2005·The Journal of Burn Care & Rehabilitation·Ankush Gosain, Richard L Gamelli
Jul 16, 2008·Annals of the Rheumatic Diseases·T L RiveraJ P Buyon
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Patricia LópezAna Suárez
Feb 11, 2015·Modern Rheumatology·Piotr PiotrowskiPaweł P Jagodziński
Jan 24, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christopher Sjöwall, Jonas Wetterö
Nov 23, 2006·International Journal of Immunogenetics·S N DasV Kapuria
Nov 28, 2008·Arthritis and Rheumatism·Gulnara MamyrovaUNKNOWN Childhood Myositis Heterogeneity Collaborative Study Group
Apr 23, 2008·Orvosi hetilap·Tamás GátiGyörgy Nagy
Sep 24, 2011·Clinical & Developmental Immunology·Hwa Chia ChaiKek Heng Chua
Jun 18, 2017·Journal of the American Society of Nephrology : JASN·Dawn J CasterKenneth R McLeish
May 3, 2019·Clinical and Experimental Medicine·Fabiano Aparecido de MedeirosAndréa Name Colado Simão
Jan 15, 2014·Molecular Biology Reports·Hanan Hosni AhmedHeba Mohamed Abdelhafiz Morsi
Mar 18, 2008·Medicine·April BinghamUNKNOWN Childhood Myositis Heterogeneity Study Group
Mar 7, 2021·Viruses·Gloria Pérez-RubioRamcés Falfán-Valencia
Jun 4, 2021·Infection and Drug Resistance·Ghada GalalAmr Zaghloul
Nov 11, 2008·Seminars in Arthritis and Rheumatism·Liang-Jing LuMichael H Weisman
Apr 8, 2009·Journal of Autoimmunity·Anura Hewagama, Bruce Richardson

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