Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants

Free Radical Research
Betti GiustiCarlo Dani

Abstract

We aimed to identify specific polymorphisms of genes encoding for superoxide dismutase (SOD) 1 (cytoplasmic Cu/ZnSOD), SOD2 (mitochondrial MnSOD), SOD3 (extracellular Cu/ZnSOD) and CAT in a cohort of preterm infants and correlate their presence to the development of respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), intraventricular haemorrhage (IVH) and retinopathy of prematurity (ROP). We carried out a retrospective study to evaluate the allele frequency and the genotype distribution of polymorphisms of SODs and CAT in a population of preterm neonates (n = 152) with a gestational age ≤ 28 weeks according to the presence or absence of RDS, BPD, IVH and ROP. Moreover, we evaluated through the haplotype reconstruction analysis whether combinations of the selected polymorphisms are related to the occurrence of RDS, BPD, IVH and ROP. We found that rs8192287 SOD3 polymorphism is an independent protective factor for all grade IVH, while rs4880 and rs5746136 SOD2 polymorphisms are associated with a lower gestational age (rs4880, rs5746136) and birth weight (rs4880). Haplotypes reconstruction showed that SOD1 (GG) decreased the risk of RDS, IVH and ROP; SOD2 (GT) increased the risk of BPD and decreased the risk of ...Continue Reading

References

Jul 31, 1992·Behavioural Brain Research·L S de VriesL M Dubowitz
Jun 1, 1995·Pediatric Pulmonology·M R Pierce, E Bancalari
May 29, 1998·The New England Journal of Medicine·A V Drack
Jul 30, 1999·Biochemical and Biophysical Research Communications·S HiroiA Kimura
Oct 26, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G F Van LandeghemP M Andersen
Sep 6, 2001·Intensive Care Medicine·E GittoI Barberi
Apr 2, 2003·Seminars in Neonatology : SN·Ola Didrik Saugstad
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Irina A BuhimschiCarl P Weiner
May 26, 2004·Controlled Clinical Trials·Robert J HardyUNKNOWN Early Treatment for Retinopathy of Prematurity Cooperative Group
Aug 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·C DaniF F Rubaltelli
Jul 5, 2005·Pediatrics·William V GoodUNKNOWN Early Treatment for Retinopathy of Prematurity Cooperative Group
Aug 4, 2005·Journal of Toxicology and Environmental Health. Part a·Yu-Mei HsuehChien-Jen Chen
Dec 3, 2005·Pediatrics·Richard A EhrenkranzUNKNOWN National Institutes of Child Health and Human Development Neonatal Research Network
Apr 25, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C W MakM M W Chan-Yeung
Mar 23, 2007·Genes, Brain, and Behavior·H W WienerR C P Go
Aug 16, 2008·American Journal of Respiratory and Critical Care Medicine·Morten DahlBørge G Nordestgaard
Oct 15, 2008·Pediatric Research·Emin Maltepe, Ola Didrik Saugstad
Dec 26, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Klára RostaAgota Vér
May 30, 2009·Free Radical Biology & Medicine·Lu Miao, Daret K St Clair
Oct 10, 2009·Pediatric Research·Praveen Ballabh
Nov 21, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yumiko WatanabeYutaka Imai

❮ Previous
Next ❯

Citations

May 8, 2014·Oxidative Medicine and Cellular Longevity·Chiara Poggi, Carlo Dani
Dec 4, 2013·Antioxidants & Redox Signaling·Sara K Berkelhamer, Kathryn N Farrow
Apr 16, 2013·Seminars in Perinatology·Gary M Shaw, Hugh M O'Brodovich
Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chiara PoggiCarlo Dani
Dec 18, 2014·Pediatric Research·Venkatesh SampathJohn M Dagle
Oct 20, 2015·Seminars in Perinatology·Mary Elizabeth Hartnett, C Michael Cotten
Oct 17, 2015·Seminars in Perinatology·Charitharth Vivek Lal, Namasivayam Ambalavanan
Apr 5, 2017·Antioxidants & Redox Signaling·Maurice J HuizingEduardo Villamor
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
Aug 14, 2019·Annals of Clinical and Translational Neurology·Jinbin XuDavid M Holtzman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Chiara PoggiCarlo Dani
International Ophthalmology Clinics
B D Simons, J T Flynn
© 2021 Meta ULC. All rights reserved