Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass

The Journal of Thoracic and Cardiovascular Surgery
J GrünenfelderM Turina

Abstract

Cardiopulmonary bypass induces a rise in cytokines released by activated monocytes. The apolipoprotein E and the tumor necrosis factor beta polymorphisms are risk factors for atherosclerosis. The aim of the study was to investigate whether the genetic variants of apolipoprotein E (APOE*E4) and tumor necrosis factor beta (TNFB*A329G) affect cytokine release after cardiopulmonary bypass. Thirty-eight patients underwent standard coronary artery bypass grafting procedures. Genotyping for APOE*E4 and TNFB*A329G was performed. Concentrations of interleukin 8 and tumor necrosis factor alpha were measured for 48 hours after surgery. Clinical data were collected prospectively. Fourteen patients (37%) carried the combination non-APOE*E4/wild-type TNFB*A329, 12 patients (32%) showed non-APOE*E4/TNFB*A329G, 9 patients (24%) had APOE*E4/TNFB*A329G, and 3 patients (7%) had APOE*E4/wild-type TNFB*A329. Total amount of tumor necrosis factor alpha was significantly higher in patients carrying the combination APOE*E4/TNFB*A329 than in those carrying non-APOE*E4/wild-type TNFB*A329 (P <.0001). Clinical data were similar except for intubation time and amount of transfusion, which were significantly increased in patients with genetic polymorphisms ...Continue Reading

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Citations

Apr 1, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Johannes BoehmRobert Bauernschmitt
Aug 19, 2011·Biodemography and Social Biology·Sarinnapha VasunilashornHooman Allayee
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Masatoshi TakedaRamón Cacabelos
Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Michael L JamesDaniel T Laskowitz
Feb 3, 2009·The Journal of Headache and Pain·Ravi GuptaManjeet Singh Bhatia
Jun 11, 2015·Best Practice & Research. Clinical Anaesthesiology·Julie L Huffmyer, Danja S Groves
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Mar 11, 2010·Anesthesiology·David L McDonaghUNKNOWN Neurologic Outcome Research Group
Mar 21, 2006·Current Opinion in Anaesthesiology·Christine Rinder

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