Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of North Central India: an association study with pulmonary tuberculosis

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
G MishraPramod Kumar Tiwari

Abstract

The association of genetic variants of chemokines, CCL2 [MCP-1 (monocyte chemoattractant protein-1)], CCL5 [RANTES (regulated on activation, normal T-cell expressed and secreted)] and their receptors CCR2 and CCR5, respectively, earlier reported to be associated with susceptibility to pulmonary tuberculosis (PTB) in certain ethnic populations, were explored in Sahariya tribe, a primitive tribe of North Central India having a high prevalence of TB. We genotyped 215 cases and 215 controls of Sahariya tribe for polymorphisms in CCL2 (-2518A/G, -362G/C) by PCR-RFLP method and in CCR2 (V64I), CCL5 (-403G/A, -28C/G) and CCR5 (-59029G/A) by ARMS-PCR method. The frequencies of 'AA' genotype and 'A' allele of -403G/A were found significantly higher in cases than in controls (OR, 2.616 [95%CI, 1.302-5.320] and OR, 1.348 [95%CI, 0.980-1.853], respectively). Conversely, the frequencies of 'AA' genotype and 'A' allele of V64I were significantly (p=0.05 and 0.04, respectively) higher in controls than in cases. Also, the "AA" genotype of V64I was found to provide significant (p=0.05) protection against high bacillary load (3+). Likewise, the comparison of frequencies of different combinations of these polymorphisms further strengthens the ass...Continue Reading

References

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A M Ginsberg
Apr 5, 2001·Trends in Immunology·V Appay, S L Rowland-Jones
Sep 13, 2001·Stem Cells·K Christopherson, R Hromas
Sep 19, 2003·Lancet·Thomas R FriedenChristopher Dye
Apr 13, 2004·AIDS·Emi E NakayamaTatsuo Shioda
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
May 17, 2007·International Journal of Immunogenetics·G KaurN K Mehra
Apr 8, 2010·Journal of Leukocyte Biology·Bridget VesoskyGillian Beamer
Jun 29, 2011·International Journal of Immunogenetics·P SelvarajK Afsal

❮ Previous
Next ❯

Citations

Sep 24, 2013·Genetic Testing and Molecular Biomarkers·Bin MaoFengling Zhuo
Jun 25, 2013·Tropical Medicine & International Health : TM & IH·Najwa MhmoudW J Wendy van de Sande
Sep 4, 2013·International Journal of Immunogenetics·B SinghP Selvaraj
Sep 3, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gunja MishraNarinder K Mehra
Aug 13, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tian GongYukai Du
Oct 24, 2017·International Journal of Immunogenetics·M QrafliK Sadki
Sep 27, 2016·Prague Medical Report·Hamid Reza KouhpayehMohammad Hashemi
Mar 2, 2019·Pathogens and Global Health·Ravi PrakashPramod Kumar Tiwari
Mar 27, 2020·International Journal of Immunogenetics·Joel Henrique EllwangerJosé Artur Bogo Chies
Sep 1, 2018·Frontiers in Medicine·Murugesan HarishankarRamalingam Bethunaickan
Apr 3, 2018·Genetic Testing and Molecular Biomarkers·Alexander VarzariIgor V Deyneko
Oct 28, 2016·Microbiology Spectrum·Vivek Naranbhai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.