Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India

Archives of Toxicology
Daya Shankar Lal SrivastavaRama Devi Mittal

Abstract

The role of low penetrance genes and environmental factors in the etiology of bladder cancer (CaB) is unclear, but may involve genetic and environmental factors. Most environmental pro-carcinogens require metabolic activation by phase I enzymes (CYP450s), However, phase II enzyme (i.e., microsomal epoxide hydrolase: mEH) is mainly involved in the detoxification of wide variety of endogenous or exogenous carcinogens. Genetic differences in CYP1A1 gene and the mEH gene polymorphisms have been reported to be associated with susceptibility to various cancers. In our case-control study, we assess whether Msp1 polymorphism of CYP1A1 (CYP1A1*2A), and His(113) in exon 3 and Arg(139) in exon 4 of the mEH susceptibility genotypes, tobacco-use and age factors contribute to bladder cancer risk among Indians. A case-control study was conducted in 106 bladder cancer (CaB) patients and 160 age matched controls from similar ethnic background. The CYP1A1*2A and mEH genotypes were determined by polymerase chain reaction/restriction fragment length polymorphism method from DNA extracted from peripheral blood samples. Binary logistic regression model was used for assessing differences in genotype prevalence between patients and the controls. The A...Continue Reading

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Apr 2, 2004·Archives of Toxicology·Daya Shankar Lal SrivastavaRama Devi Mittal
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Citations

Jun 24, 2009·Archives of Toxicology·Hermann M Bolt, Jan G Hengstler
Mar 8, 2011·Archives of Toxicology·Klaus GolkaJan G Hengstler
Jul 11, 2013·Biochemical Genetics·Shiv Kumar GiriSanjeev Kumar Gautam
Aug 27, 2014·Archives of Toxicology·Hermann M Bolt
May 12, 2012·Mediators of Inflammation·Raynoo ThananShosuke Kawanishi
Apr 27, 2013·Environmental Toxicology and Pharmacology·Manushi SiddarthAshok K Tripathi
Mar 1, 2010·Environmental Toxicology and Pharmacology·Vivek KumarBasu Dev Banerjee
Dec 29, 2015·Urologic Oncology·Monica SankhwarSingh Rajender
Mar 11, 2016·Indian Journal of Cancer·A BagN Bag
Sep 30, 2014·Journal of Experimental & Clinical Cancer Research : CR·Xiaoqin YangGuiping Wang
Mar 22, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Manal Mohamed Makhlouf, Rania Ismail Magdy
Nov 8, 2015·Familial Cancer·Sumaira AkhtarMahmood Akhtar Kayani
Feb 23, 2013·Urologic Oncology·Monica Sankhwar, S N Sankhwar
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yu LuShan Li
Oct 1, 2020·Vox Sanguinis·Willy Albert FlegelWilliam Douglas Figg

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