Genetic polymorphisms of factor VII are not associated with arterial thrombosis

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
J CorralV Vicente

Abstract

A high plasma concentration of factor VII procoagulant activity is considered an independent risk factor for coronary heart disease. Recently, two polymorphisms of factor VII gene (insertion of a decanucleotide at -323 [A2], and the variant Q353) have been associated with 20-25% lower levels of this protein in plasma. In this study, the prevalence of these two factor VII polymorphisms were evaluated in relation to the development of acute thromboembolic events. Thus, we conducted three case-control studies of patients diagnosed with acute coronary syndromes, acute cerebrovascular events and deep venous thrombosis (101, 104 and 97 cases, respectively). No significant differences were detected in the prevalence of these polymorphisms between patients and controls, suggesting that the A1/A2 or R/Q alleles do not play an important role in the development of thromboembolic episodes.

Citations

Apr 26, 2001·Journal of Physiology and Biochemistry·J RiveraV Vicente
Feb 20, 2008·Journal of Thrombosis and Thrombolysis·Ahmet SoyluHasan Acar
Aug 31, 2012·Journal of Thrombosis and Thrombolysis·Sonia Ben-Hadj-KhalifaWassim Y Almawi
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Georg Endler, Christine Mannhalter
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lucy A Norris
Jul 10, 2003·BMC Neurology·James F MeschiaUNKNOWN Ischemic Stroke Genetics Study
Jun 11, 2009·Journal of Thrombosis and Thrombolysis·Marlena Culjak Aleksic, Jasna Mesaric
Apr 27, 2012·Journal of Thrombosis and Thrombolysis·Rupinder Kaur DograK K Talwar
Jul 2, 2010·Critical Reviews in Clinical Laboratory Sciences·Sanja Stankovic, Nada Majkic-Singh
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Michele VentiVirgilio Gallai
Dec 6, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·T P Kruthika-VinodRita Christopher
Jul 4, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S J ReadF C Barone
Mar 31, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nasrin BargahiAhmad Poursadegh Zonouzi
Jan 29, 1999·Hematology/oncology Clinics of North America·E J Neufeld
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Jane M MaguireJohn Attia
Mar 3, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jacqueline A CutlerGeoffrey F Savidge
May 11, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stanislaw LopaciukKenneth A Bauer
Mar 25, 2006·Clinical Chemistry·Marion FunkChristine Mannhalter
Apr 7, 2012·Autoimmune Diseases·Carlos A Cañas, Felipe Cañas
Nov 22, 2001·Journal of Applied Physiology·D M Herrington, K P Klein
Jun 8, 2001·Experimental Biology and Medicine·M S Williams, P F Bray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.