Genetic polymorphisms of FcγRIIa and FcγRIIIa are not predictive of clinical outcomes after cetuximab plus irinotecan chemotherapy in patients with metastatic colorectal cancer

Oncology
Seong Joon ParkTae Won Kim

Abstract

The anti-epidermal growth factor receptor monoclonal antibody cetuximab has been shown to be effective in patients with wild-type KRAS metastatic colorectal cancer (mCRC). Fragment C γ receptor (FcγR) polymorphisms may predict the effectiveness of cetuximab, but this has not been established. This study investigated the clinical relevance of FcγR gene polymorphisms and KRAS status in iri-notecan-refractory mCRC patients treated with cetuximab. The total number of irinotecan-refractory mCRC patients studied was 118. Among them, 117 and 107 patients were screened for KRAS mutations and genetic polymorphisms of FcγRIIa-131H/R and FcγRIIIa-158V/F, respectively. The association of FcγR polymorphisms and KRAS mutations with clinical outcome was analyzed. KRAS mutations were found in 33 patients (27.1%). Wild-type KRAS was associated with a better response rate (p < 0.001), longer progression-free survival (p < 0.001) and longer overall survival (p < 0.001). FcγRIIa H/H, H/R and R/R polymorphisms were observed in 54, 49 and 4 patients, respectively, and FcγRIIIa V/V, V/F and F/F polymorphisms were observed in 6, 65, and 36 patients, respectively. Clinical outcomes were not significantly associated with either FcγRIIa or FcγRIIIa polym...Continue Reading

References

Mar 31, 2000·Nature Medicine·R A ClynesJ V Ravetch
Sep 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wen-Kai Weng, Ronald Levy
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Yoshihiko KawaguchiHideki Fujii
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KuraiEiji Shimizu
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wu ZhangHeinz-Josef Lenz
Oct 6, 2007·Immunologic Research·George J Weiner
Oct 18, 2007·British Journal of Cancer·M FrattiniL Mazzucchelli
Nov 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W De RoockS Tejpar
Nov 16, 2007·The New England Journal of Medicine·Derek J JonkerMalcolm J Moore
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Astrid LièvrePierre Laurent-Puig
Mar 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonino MusolinoAndrea Ardizzoni
Apr 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto F SobreroHoward A Burris
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federica Di NicolantonioAlberto Bardelli
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frédéric BibeauFlorence Boissière-Michot
Apr 3, 2009·The New England Journal of Medicine·Eric Van CutsemPhilippe Rougier
May 14, 2009·British Journal of Cancer·I Chau, D Cunningham
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Apr 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan PanderHenk-Jan Guchelaar
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ling ZhangRami Komrokji

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Citations

May 13, 2014·Immunotherapy·Christof Seidl
Jun 24, 2014·Pharmacogenomics·Geraldine PerkinsPierre Laurent-Puig
Oct 27, 2015·Immunological Reviews·Chantal E HargreavesJonathan C Strefford
Jul 13, 2019·Current Medicinal Chemistry·Elena De MattiaErika Cecchin
Apr 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gilles ManceauPierre Laurent-Puig
Jul 6, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesco SclafaniIan Chau

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