Genetic polymorphisms of heme-oxygenase 1 (HO-1) may impact on acute kidney injury, bronchopulmonary dysplasia, and mortality in premature infants

Pediatric Research
David J AskenaziNamasivayam Ambalavanan

Abstract

Heme oxygenase 1 (HO1) catalyzes heme degradation, and offers protection for several organs, including the kidney. Genetic polymorphisms of HO-1 are associated with poor clinical outcomes in several populations. We prospectively enrolled 117 premature infants (birth weight ≤1,200 g or postgestational age ≤31 wk) and evaluated two DNA genetic variants proximal to the promoter region of HO-1 (GT(n) repeats, and -413T>A SNP). We evaluated how these polymorphisms affect two clinical outcomes: (i) Acute Kidney Injury (AKI)-rise in serum creatinine (SCr) ≥ 0.3 mg/dl or ≥ 150-200% from lowest previous value, (ii) the composite of mortality and bronchopulmonary dysplasia (BPD) defined as receipt of oxygen at 36 wk postmenstrual age. AKI occurred in 34/117 (29%) of neonates; 12/117 (10%) died; 29/105 (28%) survivors had BPD. Neonates with TT genotype at 413T>A before the HO-1 promoter had higher rates of AKI (P < 0.05). There was no difference in number of GT(n) repeats and clinical outcomes. We did not find an association between the GT(n) tandem repeat of HO-1 and AKI nor BPD/mortality. However, infants with TT genotype of the 413T>A genetic alteration had lower incidence of AKI. Further studies using larger cohorts are needed to bett...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·K A NathM E Rosenberg
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Feb 7, 2001·Critical Care Medicine·H ShimizuR Akagi
May 12, 2000·American Journal of Physiology. Renal Physiology·F ShiraishiA Agarwal
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Feb 6, 2004·American Journal of Physiology. Renal Physiology·Eric M SikorskiAnupam Agarwal
Sep 27, 2005·Current Neurovascular Research·Rita RezzaniElias A Lianos
Jul 14, 2007·International Journal of Immunogenetics·H TurpeinenJ Partanen
Nov 30, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aisling E CourtneyA Peter Maxwell
Mar 29, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aisling E Courtney, A Peter Maxwell
Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David J AskenaziStuart L Goldstein
Feb 12, 2009·Journal of Korean Medical Science·Ho Jun ChinUNKNOWN Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) members
Dec 24, 2010·Pediatric Research·Rajesh KoralkarDavid Askenazi
Jan 10, 2012·Current Opinion in Pediatrics·Jennifer G Jetton, David J Askenazi
Jan 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Angeles Fernandez-GonzalezStella Kourembanas
Mar 24, 2012·Journal of the American Society of Nephrology : JASN·Richard A ZagerKirsten Becker
Mar 27, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David J Askenazi
Jun 12, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshio ShimaMakoto Migita
Nov 28, 2013·Current Opinion in Nephrology and Hypertension·Karl A Nath

❮ Previous
Next ❯

Citations

Apr 18, 2016·Seminars in Nephrology·Vyvyca J Walker, Anupam Agarwal
May 26, 2016·Journal of Cellular and Molecular Medicine·Pu SongTianwen Gao
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·David E LeafSushrut S Waikar
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·Lisa M Curtis, Anupam Agarwal
Feb 20, 2016·Current Opinion in Infectious Diseases·Jodi M LestnerMike Sharland
Aug 2, 2020·Annals of the New York Academy of Sciences·Dylan R AddisTamas Jilling
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ruka NakasoneKazumichi Fujioka
Mar 30, 2021·American Journal of Physiology. Renal Physiology·Lisa M CurtisAnupam Agarwal

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA
PCR
electrophoresis
Assay

Clinical Trials Mentioned

NCT01430156

Software Mentioned

SAS

Related Concepts

Related Feeds

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
David J AskenaziRussell L Griffin
Journal of Perinatology : Official Journal of the California Perinatal Association
J CheckK K Mestan
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Minesh KhatriDavid L Tirschwell
American Journal of Respiratory and Critical Care Medicine
Peter M MouraniSteven H Abman
© 2022 Meta ULC. All rights reserved