Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer

Cancer Research
Dominique S MichaudRichard B Hayes

Abstract

Chronic intraprostatic inflammation is suspected to play a role in the pathogenesis of prostate cancer. Polymorphisms in cytokine genes can influence inflammation and immune response and may be related to the risk of prostate cancer. Four common single nucleotide polymorphisms (SNPs) in the genes encoding interleukin-1B (IL-1B), IL-6, and IL-8 were assessed in 503 prostate cancer cases and 652 controls, and three SNPs in IL-10 were assessed in an additional 817 prostate cancer cases and 1,190 controls (for a total of 1,320 prostate cancer cases and 1,255 controls). Cases and controls were selected from the on-going Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial and were frequency matched on age, ethnicity, time-period since initial screening, and date of blood draw. Single-locus analyses were conducted using conditional logistic regression. In addition, we did a haplotype analysis for the three IL-10 SNPs tested. Overall, no associations were detected between the seven polymorphisms in the four cytokine genes examined in this study and prostate cancer risk. Further stratifying by use of nonsteroidal anti-inflammatory drugs did not modify the associations. Findings were similar for early or advanced prostate cance...Continue Reading

References

Dec 11, 1992·Science·A E KochR M Strieter
Oct 1, 1988·Theoretical Population Biology·R C Lewontin, M W Feldman
May 18, 1999·The American Journal of Pathology·B B MooreR M Strieter
Feb 24, 2001·Controlled Clinical Trials·J K GohaganUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Feb 24, 2001·Controlled Clinical Trials·B O'BrienUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Feb 24, 2001·Controlled Clinical Trials·R B HayesUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Apr 20, 2001·Cytokine & Growth Factor Reviews·P C SmithE T Keller
Dec 6, 2001·The American Journal of Pathology·D GiriM Ittmann
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Jan 24, 2002·Epidemiology·Leslie K Dennis, Deborah V Dawson
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 30, 2004·Human Molecular Genetics·Daniel J Schaid
Aug 19, 2004·Journal of the National Cancer Institute·Fredrik LindmarkJianfeng Xu

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Citations

Jul 10, 2007·Cancer Immunology, Immunotherapy : CII·Jovanny ZabaletaAugusto C Ochoa
Nov 14, 2007·Cancer Causes & Control : CCC·Jessica M Faupel-BadgerJoseph A Tangrea
May 1, 2010·Cancer Causes & Control : CCC·Jianjun ZhangFred F Kadlubar
Dec 25, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shixin BaoZhangqun Ye
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Nov 28, 2013·Nature Reviews. Clinical Oncology·Ian M ThompsonMichael J Wargovich
Feb 23, 2011·Prostate Cancer and Prostatic Diseases·N ShaoL-x Hua
Aug 2, 2012·Prostate Cancer and Prostatic Diseases·M IanniF Licastro
Jan 25, 2011·Genetic Testing and Molecular Biomarkers·Serdar OztuzcuMehmet Yavuz Coşkun
Jan 15, 2008·Carcinogenesis·L M G MoonsP D Siersema
May 29, 2009·Carcinogenesis·Jovanny ZabaletaAugusto C Ochoa
Apr 24, 2012·Carcinogenesis·Ernest K AmankwahJong Y Park
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wen-Yi HuangCharles S Rabkin
Aug 4, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paul J DluzniewskiElizabeth A Platz
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel J CarusoBal L Lokeshwar
Jun 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hasan KorkayaMax S Wicha
Oct 4, 2011·The Journal of Clinical Investigation·Hasan KorkayaMax S Wicha
Dec 8, 2009·Fibrogenesis & Tissue Repair·Georgina L HoldEmad M El-Omar
Nov 29, 2007·Future Oncology·Noah M HahnChristopher J Sweeney
Feb 21, 2014·BMC Cancer·Florence MenegauxUNKNOWN EPICAP Study Group
Feb 18, 2009·Cancer Immunology, Immunotherapy : CII·Calogero CarusoSonya Vasto
Feb 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei JinGuojun Li
Aug 11, 2012·Expert Opinion on Therapeutic Targets·Bin BaoFazlul H Sarkar
Jan 8, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yan-Feng ZouFen Huang
Nov 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jin-Guang YaoGuang-Fu Pang
Dec 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tanja EderKarin S Kapp
Feb 4, 2009·International Journal of Cancer. Journal International Du Cancer·Jennifer Rider StarkLorelei A Mucci
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Steven C MooreMarc J Gunter
Aug 28, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ye-Sheng WeiWei-Tong Huang
Apr 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ziliang WangGong Yang
Apr 20, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lin-Bo GaoLin Zhang

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