Abstract
Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (PNALT). A total of 121 PNALT patients did not receive any antiviral treatment but underwent periodic clinical monitoring, including repeat biopsies, for a median of 120 months. IL6-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C polymorphisms were related to histologic fibrosis progression. Among patients whose grading and staging scores increased at the end of the follow-up ≥2 Ishak points (N = 60 and N = 26, respectively), IL-6 -174G>C genotype frequencies were GG 37/66, GC 21/45, CC 2/10 (p = 0.041) and GG 18/66, GC 8/45, CC 0/10 (p = 0.040), respectively. The following frequencies were observed for the 572G>C polymorphism: GG 50/105, GC 10/16, CC 0/0, and GG 19/105, GC 7/16, CC 0/0, respectively. Grading progression was independently associated with carriage of the G allele in -174G>C polymorphism (oddd ratio = 5.07%, 95% confidence interval = 0.959-26.8, p = 0.023). Staging progression was independently associate...Continue Reading
References
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Mar 20, 1998·International Reviews of Immunology·T Hirano
Oct 14, 1998·The Journal of Clinical Investigation·D FishmanP Woo
Jul 15, 2000·Seminars in Liver Disease·A Wasley, M J Alter
Sep 7, 2001·Transplantation·E D CoxP J Blair
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Martinot-PeignouxP Marcellin
Jul 24, 2002·Tissue Antigens·L-H TsengJ A Hansen
Oct 24, 2002·Human Immunology·Ashley MeenaghDerek Middleton
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·S L FerrariS L Greenspan
Mar 29, 2003·Journal of Hepatology·Chee-Kin HuiTeresa Lyn Wright
May 20, 2003·Experimental & Molecular Medicine·Byung Lae ParkHyoung Doo Shin
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 4, 2004·Seminars in Liver Disease·Nezam H Afdhal
Oct 28, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A AlbertiG Sebastiani
Dec 17, 2005·Journal of Hepatology·Julien MassardThierry Poynard
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan J Feld, T Jake Liang
Apr 28, 2006·Journal of Viral Hepatitis·M PersicoR Torella
Apr 28, 2006·Journal of Viral Hepatitis·S BoccatoA Alberti
Jun 3, 2006·Medical Microbiology and Immunology·Jürgen Scheller, Stefan Rose-John
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wendy CozenSue A Ingles
Feb 12, 2008·Trends in Molecular Medicine·Willscott E Naugler, Michael Karin
Sep 26, 2008·Pancreas·Enrique de-MadariaMiguel Pérez-Mateo
Sep 30, 2008·Arthritis and Rheumatism·Andrew GordonJ Mark Wilkinson
Feb 24, 2009·Journal of Hepatology·Takashi KumadaMasashi Fujimori
Feb 24, 2009·Bone Marrow Transplantation·Z AmbruzovaM Petrek
Apr 24, 2009·Genes and Immunity·L J YeeUNKNOWN Virahep-C Study
Jul 15, 2009·The Journal of Infection·Carlo FabrisMario Pirisi
Citations
Sep 18, 2013·Cytokine·Tatsuo KandaOsamu Yokosuka
May 21, 2013·The Journal of Infectious Diseases·Audrey L FrenchSeema N Desai
Oct 29, 2011·Virology Journal·Quentin LepillerGeorges Herbein
Jan 25, 2013·Viruses·Monika RauAndreas Geier
May 16, 2013·World Journal of Gastroenterology : WJG·Lydia GiannitrapaniGiuseppe Montalto
May 10, 2011·International Journal of Biological Sciences·Hua WangBin Gao
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying LiuJie-jun Wang
Nov 26, 2015·Current Pathobiology Reports·Jun XuTatiana Kisseleva
Jul 28, 2015·Journal of Medical Virology·Kentaro Matsuura, Yasuhito Tanaka
Oct 9, 2015·Genes and Immunity·G ZhangX Chen
Oct 16, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A PanayidesUNKNOWN Hellenic Sepsis Study Group
Jun 28, 2011·Journal of Hepatology·Judith Aron-WisnewskyJean-Louis Pépin
Mar 5, 2015·Hepatitis Monthly·Mustafa CengizSeren Ozenirler
Sep 28, 2016·Viral Immunology·Shafiq Ur RehmanIshtiaq Qadri
Nov 5, 2016·PeerJ·Zoran BogdanovićJanoš Terzić
Feb 1, 2017·Immunology·Fabio C O F CachemCleonice A M Bento
Feb 2, 2016·The Journal of Investigative Dermatology·Mamiko TosaMohammad Ghazizadeh
Mar 16, 2017·Balkan Journal of Medical Genetics : BJMG·T MotawiM Houssen
Jun 21, 2019·Molecular Genetics & Genomic Medicine·Yuzhu SongA-Mei Zhang
Jul 21, 2020·World Journal of Hepatology·Cliviany Borges da SilvaLuciana Diniz Silva
Sep 19, 2015·World Journal of Clinical Cases·Nicola CoppolaEvangelista Sagnelli
Aug 30, 2016·World Journal of Gastroenterology : WJG·Mahmoud Fathy DondetiRoba Mohamed Talaat
Dec 14, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kentaro Matsuura, Yasuhito Tanaka
Feb 9, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Diego Alves VieiraLuciana Diniz Silva
Apr 9, 2020·Infectious Agents and Cancer·Faisal AdnanMuhammad Ismail Khan
Jul 29, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Yasser B M AliIbrahim H El-Sayed