Genetic polymorphisms of major house dust mite allergens

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
S PiboonpocanunW R Thomas

Abstract

Polymorphic sequence substitutions in the major mite allergens can markedly affect immunoglobulin E binding and T cell responses, but there are few studies on environmental isolates from Dermatophagoides pteronyssinus and none for D. farinae. To determine the sequence variation of the group 1 and 2 allergens from environmental D. pteronyssinus and D. farinae. RNA from each species was isolated from homes in Bangkok and the sequence of Der p 1, Der p 2, Der f 1, and Der f 2 determined from cDNA produced by high fidelity polymerase chain reactions. The enlarged data set revealed preferred amino acid substitutions in residues 19, 81, and 215 of Der p 1 as well as sporadic changes. Der p 2 showed frequent variations with clusters of amino acid substitutions, but the canonical Der p 2.0101 was not found in any of 17 sequences. Der f 2 showed variants with clusters of substitutions similar to Der p 2 but in different amino acid positions and without any structural concordance. Der f 1 in contrast to the other allergens had few amino acid sequence substitutions. The sequence information on variants provides data important for the optimal design of allergen formulations and useful for the genetic engineering and structure-function anal...Continue Reading

References

Feb 7, 1998·The Journal of Biological Chemistry·S IchikawaF Inagaki
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R FurmonavicieneF Shakib
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·A M SmithM D Chapman
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·W A SmithW R Thomas
Jun 6, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A G Jarnicki, W R Thomas
Jun 11, 2002·Journal of Molecular Biology·U DerewendaD C Benjamin
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Ronald van Ree
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W ParkC-S Hong
Oct 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J HalesW R Thomas
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WestritschnigRudolf Valenta
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Petra A Wachholz, Stephen R Durham
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens HolmMichael D Spangfort
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kåre MenoKaare Lund

❮ Previous
Next ❯

Citations

Sep 18, 2007·Immunologic Research·Wayne R Thomas, Belinda J Hales
Apr 27, 2012·Experimental & Applied Acarology·Kyoung Yong JeongJung-Won Park
Oct 17, 2012·Experimental & Applied Acarology·Lakshmi YellaLarry G Arlian
Jan 3, 2012·The Journal of Biological Chemistry·Maksymilian ChruszczMartin D Chapman
Aug 19, 2007·International Archives of Allergy and Immunology·Kyoung Yong JeongTai-Soon Yong
Jan 26, 2008·BMC Plant Biology·Abdelmounim Hamman-KhalifaJuan de Dios Alché
May 16, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yubao CuiWeihong Shi
Jan 13, 2016·Journal of Proteome Research·Jintarat ChoopongAnchalee Tungtrongchitr
May 10, 2011·Revue des maladies respiratoires·J-C Bessot, G Pauli
Jul 8, 2010·Trends in Molecular Medicine·Wayne R ThomasWendy-Anne Smith
Dec 15, 2006·The Journal of Allergy and Clinical Immunology·Martin D ChapmanFatima Ferreira
Feb 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J ZakzukL Caraballo
Oct 5, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Wayne R Thomas
May 2, 2013·Biochimica Et Biophysica Acta·Yulia S LaptevaSergei E Permyakov
Aug 6, 2013·Methods : a Companion to Methods in Enzymology·Susanne VrtalaWayne R Thomas
Nov 2, 2012·Allergy, Asthma & Immunology Research·Kyoung Yong JeongChein-Soo Hong
Apr 14, 2011·Yonsei Medical Journal·Kyoung Yong JeongJung-Won Park
Nov 6, 2015·Allergy, Asthma & Immunology Research·Sasipa TanyaratsrisakulSurapon Piboonpocanun
Jan 31, 2012·International Archives of Allergy and Immunology·Véronique Bordas-Le FlochPhilippe Moingeon
Apr 4, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J SpiricR L Rabin
May 1, 2017·International Archives of Allergy and Immunology·Eduardo Santos da SilvaFatima Ferreira
Mar 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars H ChristensenKaare Lund
Nov 28, 2018·Allergy, Asthma & Immunology Research·Bhakkawarat KulwanichSurapon Piboonpocanun
Aug 8, 2018·Scientific Reports·Kavita ReginaldFook Tim Chew
Oct 24, 2018·International Journal of Immunopathology and Pharmacology·Ling LiYubao Cui
May 31, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomasz OsinskiMaksymilian Chruszcz
May 10, 2007·Current Opinion in Allergy and Clinical Immunology
Aug 25, 2021·Molecular Biology Reports·Nur Farah Hani AzemiHaidr Msahir Ateshan
Sep 30, 2019·International Archives of Allergy and Immunology·Eduardo Santos da SilvaNeuza Maria Alcantara-Neves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
J W ParkC-S Hong
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
B J HalesW R Thomas
The Journal of Allergy and Clinical Immunology
M D ChapmanFátima Ferreira
Protein and Peptide Letters
W R ThomasB J Hales
© 2022 Meta ULC. All rights reserved