Genetic polymorphisms of RAGE and risk of ulcerative colitis in a Chinese population

Immunology Letters
Jiafeng WangYu Zhou

Abstract

The receptor for advanced glycation end products (RAGE) and its proinflammatory ligands are critically implicated in the pathological progression of ulcerative colitis (UC). Functional polymorphisms in the regulatory elements and/or ligand-binding regions of the RAGE gene affect the expression and function of RAGE and thus may increase susceptibility to UC. In this study, a total of 266 unrelated UC patients and 247 control subjects were analyzed for 3 RAGE single nucleotide polymorphisms (SNPs) (-429 T/C, -374 T/A, and G82S) using an improved small-amplicon high resolution melting curve (HRM) analysis assay. Serum levels of soluble RAGE (sRAGE) were determined by a double sandwich ELISA system. The genotypes, alleles and haplotypes were analyzed and compared between UC patients and control subjects. Three pairs of genotyping primers for three RAGE polymorphism loci (-429 T/C, -374 T/A, and G82S) were developed based on HRM. Significant differences in the allele distribution of the G82S polymorphism was found among UC cases and controls from a Chinese population. Carriers of the RAGE G82S variant genotype were at higher risk of UC (OR=2.594, 95% CI: 1.778-3.784, P<0.001) than homozygous wild-type individuals. Further analyses r...Continue Reading

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Citations

Sep 15, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Romy M Heilmann, Karin Allenspach
Jul 15, 2018·British Journal of Pharmacology·Carlos J ArandaFermín Sánchez de Medina
Sep 6, 2018·Current Medicinal Chemistry·Fabiana Andréa MouraAmylly Sanuelly da Paz Martins
Feb 2, 2021·Journal of Biochemical and Molecular Toxicology·Mayada G ElhennawyWafaa R Mohamed

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