Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study

Cancer
S KatoP G Shields

Abstract

Gastric cancer is a multistage process, each caused by numerous factors. The objective of this study was to elucidate the risk factors for gastric cancer by using molecular epidemiologic techniques and serum markers. Serum pepsinogen I levels, pepsinogen I/pepsinogen II (I/II) ratios, serum IgG antibody against Helicobacter pylori (H. pylori), and genetic polymorphisms of cytochrome p450 2E1 (CYP2E1), glutathione-S-transferase M1 (GSTM1), and L-myc protooncogenes were analyzed in 82 persons with gastric cancer and in 151 age- and sex-matched controls, who were selected from 208 gastric cancer patients and 375 noncancer patients, respectively. Statistical analysis was performed to elucidate which risk factors for gastric cancer were contributing the most to gastric carcinogenicity. Serum pepsinogen I level (odds ratio [OR] = 1.81; 95% confidence interval [CI], 1.04-3.16) and pepsinogen I/II ratios (OR = 3.09; 95% CI, 1.74-5.49) were significantly associated with gastric cancer risk in a case-control study. Seropositivity of serum IgG antibody against H. pylori (OR = 1.25; 95% CI, 0.84-1.85) and specific genotypes of a L-myc genetic polymorphism (OR = 1.33; 95% CI, 0.59-2.99) were more commonly observed in gastric cancer cases, b...Continue Reading

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·K KawashimaS Nishimura
Mar 1, 1991·Chemical Research in Toxicology·F P GuengerichM Iwasaki
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Feb 7, 1990·Journal of the National Cancer Institute·K IshizakiJ Toguchida
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·S TamaiC C Harris
Jan 1, 1990·Drug Metabolism Reviews·C S YangJ Y Hong
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K KawashimaS Nishimura
Mar 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G N StemmermannL K Heilbrun
Oct 1, 1980·Annals of Internal Medicine·A M NomuraI M Samloff
Jan 1, 1995·Pharmacogenetics·K R Kaderlik, F F Kadlubar
Jan 1, 1995·Japanese Journal of Cancer Research : Gann·H FukudaM Katoh
May 1, 1994·Japanese Journal of Cancer Research : Gann·S TsuganeK Sugano
Jul 15, 1994·Cancer·G N Stemmermann

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Citations

Jun 21, 2014·Diagnostic Pathology·Xianhong MengBona Liu
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Jun 19, 2009·European Journal of Human Genetics : EJHG·Lei GaoHermann Brenner
Sep 14, 1999·The American Journal of Gastroenterology·G D EslickN J Talley
Sep 1, 1999·Cancer Detection and Prevention·Z F ZhangJ R Marshall

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