PMID: 9451664Feb 6, 1998Paper

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility

Journal of Clinical Gastroenterology
H HoriY Yuasa

Abstract

Many human cancers are caused by synthetic or natural chemical compounds in the environment. Esophageal squamous cell carcinoma has been reported to be epidemiologically associated with tobacco and alcohol consumption. We studied the association between genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and esophageal squamous cell carcinoma susceptibility. We examined genetic polymorphisms of the CYPIA1, GSTM1, CYPIIE1, ADH2, and ALDH2 genes in 94 Japanese patients with esophageal squamous cell carcinoma and 70 unrelated healthy Japanese persons. There were no significant differences between healthy controls and patients with esophageal cancer in the polymorphisms of the CYPIA1, GSTM1, and CYPIIE1 genes. On the other hand, there were significant differences in the ADH2 and ALDH2 polymorphisms between healthy controls and esophageal cancer patients. The ADH2(1)/ADH2(1) and ALDH2(1)/ALDH2(2) genotypes were independently and significantly higher in esophageal cancer patients than in healthy controls. Furthermore, persons with the combined genotypes ADH2(1)/ADH2(1) and ALDH2(1)/ALDH2(2) were at extraordinarily high risk for esophageal squamous cell carcinoma, with an odds ratio of 17.9 (p < 0.001). Thus pol...Continue Reading

References

Jan 1, 1975·Annual Review of Biochemistry·C Heidelberger
Jan 1, 1990·Drug Metabolism Reviews·C S YangJ Y Hong
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberT Worner
Jan 1, 1988·Annual Review of Nutrition·H K Seitz, U A Simanowski
Jan 1, 1988·CRC Critical Reviews in Biochemistry·B Mannervik, U H Danielson
Jan 1, 1984·The Medical Clinics of North America·E J BurbigeC H Halsted
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·Y MaezawaS Sakurai
Mar 1, 1995·Japanese Journal of Cancer Research : Gann·J WatanabeK Kawajiri
Jan 1, 1993·Alcohol and Alcoholism. Supplement·S Harada, T Okubo
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·C W HodgeH H Samson
Jan 1, 1994·Alcohol·J L RabinowitzR L Engen
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·S J YinS C Lee
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·T NishihiraT Kuroki
Apr 1, 1996·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F de WaardB J Slotboom

❮ Previous
Next ❯

Citations

Jul 9, 1999·The Journal of Pathology·M G van OijenP J Slootweg
Jul 10, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stewart CampbellRobin I Russell
Sep 6, 2002·Cancer Letters·Pleumjit BoonyaphiphatPuttisak Puttawibul
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Montesano, J Hall
Dec 12, 2001·Critical Reviews in Oncology/hematology·T Minamoto, Z Ronai
Mar 29, 2000·Critical Reviews in Oncology/hematology·A K Lam
May 11, 1999·Alcoholism, Clinical and Experimental Research·H TanabeY Kohgo
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C J Eriksson
Jun 27, 2003·Environmental Health Perspectives·Samir N KeladaMuin J Khoury
Apr 23, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Robea BalloM Iqbal Parker
Feb 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Dong-Ping LiM Iqbal Parker
Sep 3, 2008·World Journal of Gastroenterology : WJG·Chang-Ming GaoKazuo Tajima
Sep 2, 2010·World Journal of Gastroenterology : WJG·Shu-Juan YangChun-Xia Yang
Jan 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Long ZhangLing Ye
May 5, 2005·American Journal of Epidemiology·L F MassonJ Little
Oct 1, 2009·Gastroenterology·Adam J Bass, Matthew Meyerson
Mar 31, 2009·Gastroenterology Clinics of North America·Winson Y Cheung, Geoffrey Liu
Dec 1, 2007·The Journal of Investigative Dermatology·Lynn K PershingMaurine R Hobbs
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Akira YokoyamaHiroshi Watanabe
Oct 24, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C-S ChungH-P Wang
Jun 5, 2004·Toxicology Letters·Thomas NeuhausThomas Brüning
Apr 12, 2016·Journal of Cellular and Molecular Medicine·Anjing RenLingjun Zhu
Jun 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anita SharmaJoginder Kumar Sharma
Jul 23, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Feng-Feng GongYe-Huan Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.