Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsia

Molecular Human Reproduction
Ilona BányászJános Rigó

Abstract

Several lines of evidence support the hypothesis that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of pre-eclampsia (PE). VEGF is a key component in the regulation of vascular remodelling and the survival of cytotrophoblasts in the placenta. In this case-control study, we aimed to test whether VEGF genetic polymorphisms are associated with the risk of severe PE. We enrolled 84 nulliparous pregnant women with severe PE (PE group). Their VEGF G(+405)C and VEGF C(-2578)A genotypes were determined by PCR-restriction fragment length polymorphism (PCR-RFLP) from venous blood samples and were compared with the corresponding VEGF genotypes of 96 nulliparous patients with uncomplicated pregnancies (control group). Carriers of the VEGF(+405)G allele occurred less frequently in PE than in the control group [P = 0.039; adjusted odds ratio (aOR) = 0.28, range: 0.08-0.93]. Hypertension and proteinuria were diagnosed earlier (by 1.6 weeks and 1.9 weeks, respectively) in PE patients with VEGF(-2578)A only after adjustment of this association for risk factors of PE. Our results suggest that carriers of VEGF(+405)G allele have a decreased susceptibility to PE and that the progression of PE may be modified...Continue Reading

References

Jun 1, 1996·Journal of Cardiovascular Pharmacology·R YangH Jin
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·F LyallR Fleming
Nov 16, 1999·American Journal of Obstetrics and Gynecology·K Y LainJ M Roberts
Jan 6, 2001·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·S OngP N Baker
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Majid ShahbaziPaul N Harden
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Mar 5, 2004·Molecular Human Reproduction·Dimitrios PapazoglouEfstratios Maltezos
Mar 23, 2004·Annals of the New York Academy of Sciences·Gudmundur Jóhann ArasonGeorg Füst
Nov 6, 2004·Seminars in Nephrology·Yuval BdolahS Ananth Karumanchi
Mar 4, 2005·BMJ : British Medical Journal·Kirsten Duckitt, Deborah Harrington
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Sep 24, 2005·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins--Obstetrics

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Citations

Oct 14, 2010·Archives of Gynecology and Obstetrics·Stefanie Bussen, Dieter Bussen
Sep 12, 2008·Breast Cancer Research and Treatment·Bryan P SchneiderGeorge W Sledge
Jun 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qiong ZhouJingjing Xu
Apr 13, 2012·Human Reproduction Update·P H AndraweeraC T Roberts
May 18, 2011·BMC Pregnancy and Childbirth·Idalia Garza-VelozMargarita L Martinez-Fierro
Feb 7, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Young Ju KimHyun-Young Park
Jan 11, 2008·Journal of Perinatal Medicine·Sabine MützeWerner Rath
Jan 2, 2014·Pediatric Surgery International·Hande Ozgun KaratepeFiliz Bakar
Oct 22, 2015·The Journal of Obstetrics and Gynaecology Research·Saeedeh SalimiAnoosh Naghavi
Sep 10, 2011·American Journal of Reproductive Immunology : AJRI·Young Joo JeonNam Keun Kim
Feb 10, 2007·Gynecologic Oncology·Stephan PolterauerLukas A Hefler
May 17, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hans Ivar HanevikJarl A Kahn
Oct 30, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Prabha H AndraweeraClaire T Roberts
Oct 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Peter ChedrauiTommaso Simoncini
May 24, 2015·European Journal of Clinical Pharmacology·G H Oliveira-PaulaJose E Tanus-Santos
Jan 3, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bálint NagyJános Rigó
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Jae-Yoon ShimAhm Kim
Sep 14, 2010·American Journal of Obstetrics and Gynecology·Attila MolvarecShigeru Saito
Jun 29, 2011·Pregnancy Hypertension·Isha Agarwal, S Ananth Karumanchi
Oct 18, 2014·Archives of Gynecology and Obstetrics·Vanessa Resende Souza SilvaMarly Aparecida Spadotto Balarin
Sep 27, 2016·Clinical and Experimental Hypertension : CHE·Melissa D AmoscoCynthia P Palmes-Saloma
Jul 28, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pervin VuralMüjdat Uysal
Aug 30, 2007·Pediatric Pulmonology·Géza BokodiBarna Vásárhelyi
Feb 26, 2008·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam, Rajasingham S Jeyendran
Apr 3, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Xi HuangYan Li
Mar 22, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Howard J HechingUsha Krishnan
Jan 10, 2019·BMC Pregnancy and Childbirth·Melissa D AmoscoCynthia P Palmes-Saloma
Feb 26, 2015·Pharmacogenetics and Genomics·Immaculate Mbongo LangmiaZahurin Mohamed
Oct 28, 2019·BMC Medical Genetics·Feriha Fatima KhidriAli Muhammad Waryah
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bryan P SchneiderKathy D Miller
Apr 30, 2021·Colombia médica : CM·José Pacheco-RomeroAndrea Naranjo

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