PMID: 24344024Dec 18, 2013Paper

Genetic polymorphisms of vitamin D receptor and the risk of prostate cancer: a meta-analysis

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
Qingchuan Zhang, Yuxi Shan

Abstract

Vitamin D receptor (VDR) polymorphisms are considered to be risk factors for prostate cancer. However, previous case-control studies on the association between the variants of VDR and prostate cancer have shown contradictory results. Therefore, the role of VDR in prostate cancer remains unresolved. To investigate a potential correlation between VDR polymorphisms and prostate cancer risk, a meta-analysis of case-control and cohort studies was conducted. Eligible studies were retrieved via both computerized searches and review of references. The association of VDR polymorphisms to prostate cancer was evaluated for 4 well-known VDR polymorphisms (FokI, BsmI, ApaI and TaqI) separately. Stratified analyses on ethnic characteristics (Caucasians or Asians), cancer stage (localized or advanced) and Gleason score (<7 or >7) were performed. Fixed- or random-effect models were used to summarize the estimates of odds ratio (OR) with 95%CI according to the heterogeneity. Sensitivity analyses were conducted. A total of 40 studies met the inclusion criteria of the meta-analysis. The FF genotype illustrated a protective effect on prostate cancer in the Caucasian subgroup (OR=0.905, 95%CI 0.823, 0.995). Conversely, the bb and the TT genotypes w...Continue Reading

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