Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine.

The Journal of Headache and Pain
Giovanna GentilePaolo Martelletti

Abstract

Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein β3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.

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Mar 10, 2010·The Journal of Headache and Pain·Giovanna GentilePaolo Martelletti
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Citations

Aug 9, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M IshiiY Kiuchi
Oct 1, 2010·Internal and Emergency Medicine·Andrea NegroPaolo Martelletti
Mar 15, 2014·Pharmacogenomics·Michele VianaCherubino Di Lorenzo
Oct 11, 2014·Pharmacogenomics·Giovanna GentileMarina Borro
Jan 15, 2015·Expert Review of Neurotherapeutics·Giovanna GentileMarina Borro
Apr 11, 2013·Expert Opinion on Drug Metabolism & Toxicology·Andrea NegroPaolo Martelletti
Sep 16, 2011·Expert Opinion on Pharmacotherapy·Luana LionettoPaolo Martelletti
Sep 21, 2011·Expert Opinion on Drug Metabolism & Toxicology·Andrea NegroPaolo Martelletti
Feb 1, 2012·Expert Opinion on Drug Metabolism & Toxicology·Joseph McGraw, Donald Waller
Dec 15, 2010·Expert Opinion on Drug Metabolism & Toxicology·Giovanna GentilePaolo Martelletti
Sep 23, 2011·The Journal of Headache and Pain·Andrea Negro, Paolo Martelletti
Jan 20, 2011·The Journal of Headache and Pain·Paolo Martelletti
Oct 15, 2011·The Journal of Headache and Pain·Elisa BelleiLuigi Alberto Pini
Sep 4, 2012·The Journal of Headache and Pain·Cherubino Di LorenzoFilippo M Santorelli
Jul 12, 2012·Clinical Genetics·M T Smith, A Muralidharan
Sep 15, 2015·Neural Plasticity·Tzu-Hsien LaiWei-Ta Chen
Jul 4, 2015·Current Treatment Options in Neurology·Maria Adele GiamberardinoPaolo Martelletti
May 27, 2015·Revue neurologique·J-C CorvolL Lacomblez
Jul 3, 2013·The Journal of Headache and Pain·Luana LionettoPaolo Martelletti
Sep 6, 2017·Cephalalgia : an International Journal of Headache·Sarah CargninSalvatore Terrazzino
Oct 23, 2019·Pharmacogenomics·Marina BorroGiovanna Gentile
Feb 15, 2017·The Journal of Headache and Pain·Claudia Francesca GaspariniLyn Robyn Griffiths
Oct 27, 2018·Expert Opinion on Drug Metabolism & Toxicology·Matilde CapiPaolo Martelletti
May 19, 2019·The Journal of Headache and Pain·Leda Marina PomesPaolo Martelletti
Jan 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Mona Ameri ChalmerThomas Folkmann Hansen
Aug 1, 2021·The Journal of Headache and Pain·Damiana ScuteriGiacinto Bagetta

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Methods Mentioned

BETA
genotypization
electrophoresis
chip

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