PMID: 12580371Feb 13, 2003Paper

Genetic predisposition and screening in pediatric cancer

Pediatric Clinics of North America
Samart Pakakasama, Gail E Tomlinson

Abstract

Pediatricians are often the health care providers who first detect the signs and symptoms of childhood cancer. Although pediatric malignancies are rare diseases, early diagnosis is an important factor leading to high cure rates of many types of cancers including retinoblastomara, Wilms' tumor, hepatoblastoma, rhabdomyosarcoma. thyroid carcinoma, and other solid tumors. A number of familial cancer syndromes present with childhood cancers that can be recognized or diagnosed by pediatricians. The genetic origins of several syndromes have been elucidated. Genetic testing is not yet available for all of these inherited cancers. A frequently updated list of genetic tests is available at www.genetests.org. The ordering and interpreting of genetic tests, however, is often best done by trained genetic counselors. The pediatrician will play a vital on-going role in following the at-risk child. In many of syndromes discussed, the cost effectiveness of the tests as well as that of any potential intervention needs further study. The role of the subtle genetic polymorphisms in pediatric tumorigenesis. many more of which will undoubtedly be described in the coming years, has not yet been translated into defined needs for interventions. Perhap...Continue Reading

References

Jun 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·J A CarneyS A Lovestedt
May 14, 1992·The New England Journal of Medicine·J ToguchidaM S Sasaki
Nov 1, 1991·The Journal of Pediatrics·F M GiardielloS R Hamilton
Dec 26, 1991·The New England Journal of Medicine·M SwiftC L Chase
Aug 1, 1987·Cancer Genetics and Cytogenetics·D G Jagelman
Nov 1, 1986·American Journal of Medical Genetics·L HerreraA A Sandberg
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Nov 16, 1994·Journal of the National Cancer Institute·J WagnerD Malkin
Mar 1, 1994·Gut·A K GurbuzS R Hamilton
Apr 12, 1996·Science·C E YuG D Schellenberg
Dec 11, 1996·American Journal of Medical Genetics·R M Hughes-BenzieA E MacKenzie
Apr 29, 1998·American Journal of Human Genetics·K C SippelT P Dryja
Jun 17, 1998·Journal of Pediatric Hematology/oncology·B A GrunerS D Weitman
Apr 13, 1999·Pediatric Radiology·R C MurphyJ B Campbell
Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Chakraverty, I D Hickson
Oct 6, 1999·American Journal of Medical Genetics·H T HenneveldA J van Essen
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Mar 10, 2001·Experimental Cell Research·K Kondo, W G Kaelin
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·L BertarioUNKNOWN Hereditary Colorectal Tumours Registry
Jul 27, 2001·American Journal of Medical Genetics·L L WangS E Plon

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Citations

Jul 28, 2011·JAMA : the Journal of the American Medical Association·Mohammed OrloffCharis Eng
Mar 19, 2004·Pathology Oncology Research : POR·Károly Méhes, György Kosztolányi
Feb 22, 2012·Current Oncology Reports·Sidnei Epelman
Feb 27, 2010·Journal of Pediatric Hematology/oncology·John A D'Orazio
Sep 29, 2011·Pediatric Blood & Cancer·Joshua D Schiffman
Nov 19, 2013·Histopathology·Cheryl M CoffinScott C Borinstein
Jan 22, 2011·Pediatric Blood & Cancer·Britney McMurterConrad V Fernandez
Dec 1, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ryan SwinneyGail Tomlinson
Jan 8, 2010·Pediatric Blood & Cancer·Raid AminChatchawin Assanasen
Sep 24, 2004·Pediatric Blood & Cancer·Stella M Davies
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Sara KnapkeJoshua D Schiffman
Jun 29, 2014·Molecular Biology Reports·Gisele M VasconcelosUNKNOWN Brazilian Embryonal Tumor Group
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karl-Johan StjernfeltIngrid Øra

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