Genetic predisposition to atorvastatin-induced myopathy: a case report

Journal of Clinical Pharmacy and Therapeutics
M Francesca NotarangeloD Ardissino

Abstract

The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increased risk of myotoxicity. Our objective is to report on two cases of statin-induced myopathy occurring in a family with two patients who are carriers of the loss of function SLCO1B1 genetic variant and to briefly review the related literature. Patient 1, a 48-year-old man with history of coronary artery disease, experienced rapidly evolving muscle pain and weakness of the extremities during treatment with atorvastatin 40 mg. Patient 2, a 65-year-old man, father of patient 1, had symptoms similar to those of his son after 2 weeks' treatment with the same statin. Atorvastatin was stopped in both cases, and symptoms resolved. On the basis of family relationship between the two patients, it was possible to hypothesize a genetic basis for the myopathy. Genotyping showed the patients to be carriers of the rs4363657 polymorphism of SLCO1B1 gene. The two cases reported here and the brief literature review emphasize the impact of genetic factors on th...Continue Reading

References

Apr 4, 2003·JAMA : the Journal of the American Medical Association·Paul D ThompsonRichard H Karas
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Oct 17, 2009·Journal of the American College of Cardiology·Deepak VooraGeoffrey S Ginsburg
Jan 1, 2010·Atherosclerosis·Abhijit GhatakPaul D Thompson
Jan 22, 2010·Genome Medicine·Bas Jm PetersAnke-Hilse Maitland-van der Zee

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Citations

Nov 28, 2013·European Journal of Human Genetics : EJHG·Marc TremblayDiane Brisson
Oct 18, 2016·Drug Safety - Case Reports·Stephanie ChamBeatrice A Golomb

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