Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies.

Journal of Oncology
Elena BonoraGiovanni Romeo

Abstract

Familial thyroid cancer has become a well-recognized entity in patients with thyroid cancer originating from follicular cells, that is, nonmedullary thyroid carcinoma. The diagnosis of familial thyroid cancer provides an opportunity for early detection and possible prevention in family members. Understanding the syndromes associated with familial thyroid cancer allows clinicians to evaluate and treat patients for coexisting pathologic conditions. About five percents of patients with well-differentiated thyroid carcinoma have a familial disease. Patients with familial non-medullalry thyroid cancer have more aggressive tumors with increased rates of extrathyroid extension, lymph node metastases, and frequently show the phenomenon of "anticipation" (earlier age at disease onset and increased severity in successive generations). So far, four predisposition loci have been identified in relatively rare extended pedigrees, and association studies have identified multiple predisposing variants for differentiated thyroid cancer. This suggests that there is a high degree of genetic heterogeneity and that the development of this type of tumor is a multifactorial and complex process in which predisposing genetic variants interact with a nu...Continue Reading

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Citations

Jun 6, 2013·Thyroid : Official Journal of the American Thyroid Association·Haggi Mazeh, Rebecca S Sippel
May 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Sandya LiyanarachchiAlbert de la Chapelle
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Jun 22, 2021·International Journal of Endocrinology and Metabolism·Susan ShafieiSeyed Rasoul Zakavi
Jun 29, 2021·Frontiers in Endocrinology·Marcelo CorreiaManuel Sobrinho-Simões

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