Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study

BMJ : British Medical Journal
Agustin CeraniJ Brent Richards

Abstract

To determine if genetically increased serum calcium levels are associated with improved bone mineral density and a reduction in osteoporotic fractures. Mendelian randomisation study. Cohorts used included: the UK Biobank cohort, providing genotypic and estimated bone mineral density data; 25 cohorts from UK, USA, Europe, and China, providing genotypic and fracture data; and 17 cohorts from Europe, providing genotypic and serum calcium data (summary level statistics). A genome-wide association meta-analysis of serum calcium levels in up to 61 079 individuals was used to identify genetic determinants of serum calcium levels. The UK Biobank study was used to assess the association of genetic predisposition to increased serum calcium with estimated bone mineral density derived from heel ultrasound in 426 824 individuals who had, on average, calcium levels in the normal range. A fracture genome-wide association meta-analysis comprising 24 cohorts and the UK Biobank including a total of 76 549 cases and 470 164 controls, who, on average, also had calcium levels in the normal range was then performed. A standard deviation increase in genetically derived serum calcium (0.13 mmol/L or 0.51 mg/dL) was not associated with increased estima...Continue Reading

References

Aug 19, 1999·The New England Journal of Medicine·T D ThacherG M Chan
Aug 10, 2000·Nature·H Van EschK Devriendt
Oct 3, 2000·The American Journal of Medicine·B BashaA M Parfitt
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Mar 17, 2004·The Proceedings of the Nutrition Society·Susanne Bügel
Feb 17, 2006·The New England Journal of Medicine·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
May 30, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Darcey L H SmithStephen D Zucker
May 30, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Rajiv BhambriAmbrish Mithal
Jul 8, 2008·Reviews in Endocrine & Metabolic Disorders·Philip R FischerJohn M Pettifor
May 6, 2009·Human Molecular Genetics·Andrew D JohnsonJacqueline C Witteman
Dec 17, 2009·Pediatric Radiology·Teresa ChapmanKenneth Feldman
Feb 26, 2010·The Journal of Nutrition·Regan L BaileyMary Frances Picciano
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kari SalovaaraHeikki Kröger
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Arti BhanD Sudhaker Rao
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Jul 20, 2010·Human Molecular Genetics·Tae-Wook KangYong Sung Kim
Oct 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alexandra PapaioannouUNKNOWN Scientific Advisory Council of Osteoporosis Canada
Oct 16, 2010·Clinical Rheumatology·Laia GifreNúria Guañabens
Mar 10, 2011·Diabetes·Aldi T KrajaIngrid B Borecki
Apr 16, 2011·Public Health Nutrition·A Catharine Ross
Nov 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MoayyeriE M Lewiecki
Jan 23, 2013·Annals of Internal Medicine·Virginia A Moyer, UNKNOWN U.S. Preventive Services Task Force
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Mar 7, 2014·Statistics in Medicine·Michael BaiocchiDylan S Small
May 13, 2014·Nature Genetics·So-Youn ShinNicole Soranzo
Jul 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joshua R LewisRichard L Prince
Aug 13, 2014·Therapeutic Advances in Drug Safety·Mark J BollandIan R Reid
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Feb 19, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E V McCloskeyH Johansson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess

❮ Previous
Next ❯

Citations

Oct 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Gloria Hoi-Yee LiChing-Lung Cheung
Sep 9, 2020·Current Osteoporosis Reports·M A ChristouD Karasik
Dec 23, 2019·Journal of Orthopaedic Surgery and Research·Minbo LiuZhongxin Zhu
Dec 12, 2019·Frontiers in Endocrinology·Jie ZhengJonathan H Tobias
Nov 3, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Toshihiro Sugiyama
Dec 6, 2020·Current Opinion in Lipidology·Susanna C Larsson
Nov 10, 2020·Frontiers in Endocrinology·Katerina Trajanoska, Fernando Rivadeneira
Feb 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Zihao QuShigui Yan
Apr 18, 2021·Current Osteoporosis Reports·R LiCarolina Medina-Gomez
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jing-Yi SunGuiyou Liu
Oct 15, 2020·The Journal of Clinical Endocrinology and Metabolism·Tao ZhouLu Qi
Jun 19, 2021·Current Opinion in Endocrine and Metabolic Research·Caroline M Gorvin
Aug 28, 2021·Nutrients·Katharina da Silva Lopes, Sarah Krull Abe

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Phenoscanner
BOLT
R
METAL
MendelianRandomization
R package MendelianRandomization
RStudio

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BMJ : British Medical Journal
Katerina TrajanoskaGEFOS/GENOMOS consortium and the 23andMe research team
Arteriosclerosis, Thrombosis, and Vascular Biology
Dipender GillMike Laffan
© 2021 Meta ULC. All rights reserved