PMID: 3767012Nov 1, 1986Paper

Genetic predisposition to liver damage after halothane anesthesia in guinea pigs

Anesthesia and Analgesia
C A LunamP M Hall

Abstract

Three 4-hr normoxic (21% oxygen) exposures to 1% halothane administered 3 days apart were associated with elevations in serum alanine aminotransferase (ALT) activity in four of 20 guinea pigs after the initial and third exposures. Serum alanine aminotransferase values were not measured after the second anesthetic. Susceptibility was defined as an ALT level greater than 300 IU/L after halothane. Nonsusceptible animals, that is, animals without significant increases in ALT values after halothane, remained nonsusceptible after reexposure. Serum alanine aminotransferase values after the first and third anesthesias were significantly correlated (rs = 0.86, P less than 0.001). Two exposures of another 30 guinea pigs at a 5-week interval resulted in high elevations of ALT in the same eight animals after both anesthetics. In contrast, after an initial exposure nonsusceptible animals remained nonsusceptible upon reexposure. Serum alanine aminotransferase levels after the first and second anesthetics were significantly correlated (rs = 0.85, P less than 0.001). The proportion of first generation (F1) males with elevated ALTs whose parents were susceptible to halothane hepatotoxicity (HH) was significantly higher than the proportion of ma...Continue Reading

Citations

Jun 1, 1996·Journal of Gastroenterology and Hepatology·G C FarrellJ Mahoney
Feb 4, 2010·The Journal of Pharmacology and Experimental Therapeutics·Christine M DuganPatricia E Ganey
Jan 1, 1989·The Australian and New Zealand Journal of Surgery·M J CousinsP D Hall
Feb 1, 1989·Journal of Applied Toxicology : JAT·S AkitaK Fujii

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