Genetic predisposition to smoking is associated with risk of rheumatoid arthritis: a Mendelian randomization study

Arthritis Research & Therapy
Yu QianYingying Mao

Abstract

Although observational epidemiological studies have found that smoking is positively associated with risk of rheumatoid arthritis (RA), assessing the causality of this relationship has remained elusive because conventional observational studies are susceptible to bias such as confounding and reverse causation. Here, we applied the Mendelian randomization (MR) approach to examine the potential causal relationship between smoking and risk of RA. Summary statistics data for RA were obtained from a meta-analysis of genome-wide association studies (GWAS), including 14,361 RA cases and 43,923 controls of European ancestry. The instrumental variables (IV) and the genetic association estimates for smoking initiation and lifetime smoking were obtained from a GWAS meta-analysis including 1,232,091 individuals and a GWAS of 462,690 individuals of European ancestry, respectively. MR analyses were performed using the inverse-variance weighted (IVW) method and supplemented with the weighted-median method. Potential pleiotropy was assessed using the MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test and MR-Egger regression. Sensitivity analyses were further performed to test the robustness of the association. We found that compared with ...Continue Reading

References

Dec 5, 2006·Current Opinion in Rheumatology·Lars KlareskogLars Alfredsson
Mar 19, 2011·International Journal of Epidemiology·Stephen BurgessUNKNOWN CRP CHD Genetics Collaboration
Apr 24, 2013·Arthritis Research & Therapy·Daniela Di GiuseppeAlicja Wolk
Jan 7, 2014·Nature·Yukinori OkadaRobert M Plenge
Mar 7, 2014·Arthritis Research & Therapy·Daniela Di GiuseppeAlicja Wolk
Dec 6, 2014·International Journal of Molecular Sciences·Kathleen ChangJae Il Shin
Jan 30, 2015·American Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
Apr 12, 2017·International Journal of Epidemiology·Olena O Yavorska, Stephen Burgess
Jun 15, 2017·Lancet·Iain B McInnes, Georg Schett
Nov 23, 2017·JAMA : the Journal of the American Medical Association·Connor A EmdinSekar Kathiresan
Jul 14, 2018·BMJ : British Medical Journal·Neil M DaviesGeorge Davey Smith

❮ Previous
Next ❯

Citations

Jun 24, 2020·Arthritis Research & Therapy·Xia Jiang, Lars Alfredsson
Jun 13, 2020·Journal of Neurology·Marijne Vandebergh, An Goris
May 18, 2021·Genetic Epidemiology·Philip H AllmanHemant K Tiwari

❮ Previous
Next ❯

Software Mentioned

PRESSO
MendelianRandomization
MR
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.