Genetic profile of cumulative mutational damage associated with early pulmonary adenocarcinoma: bronchioloalveolar carcinoma vs. stage I invasive adenocarcinoma

The American Journal of Surgical Pathology
Eizaburo SasatomiSamuel A Yousem

Abstract

To detect the possible genetic alterations characteristic of bronchioloalveolar carcinoma (BAC) and to study molecular genetic factors responsible for determining the biologic aggressiveness of pulmonary adenocarcinoma, comparative analysis of loss of heterozygosity (LOH) on 9 chromosomal regions was performed in 14 BACs and in 20 stage I adenocarcinomas (AD). The most frequently affected chromosome regions in BAC were 8q and 17p. In stage I AD, more than 60% of the cases showed LOH of 1p, 3p, 5q, 7q, 17p, and 18q loci, and LOH of 1p, 3p, 7q, and 18q was observed with greater frequency than in BAC (P < 0.05). Fractional allele loss (FAL) was significantly greater in stage I AD than in BAC (P < 0.001). In cases with microdissection of multiple sites, intratumoral heterogeneity of LOH status was observed in 73% of BAC and 94% of stage I AD, and homogeneous distribution of LOH of 9p was unique to BAC. The high FAL value was associated with a poor prognosis of BAC, but this trend did not reach statistical significance (P = 0.098). In stage I AD, no correlation was found between LOH of particular chromosomal region or FAL and clinical outcome. LOH of 1p, 3p, 7q, and 18q was associated with invasive properties of pulmonary AD and may...Continue Reading

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Citations

Jul 30, 2010·The Annals of Thoracic Surgery·Susan D Moffatt-BruceCharles L Hitchcock
Jun 17, 2005·The American Journal of Surgical Pathology·Sanja DacicSamuel A Yousem
May 29, 2007·The American Journal of Surgical Pathology·Sylvie LantuejoulGiulio Rossi
May 13, 2010·International Journal of Surgical Pathology·Giuseppe PelosiGiuseppe Viale
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan J RazDavid M Jablons
Jan 16, 2010·Archives of Pathology & Laboratory Medicine·Lucian R Chirieac, Douglas B Flieder
Jul 10, 2007·Archives of Pathology & Laboratory Medicine·Samuel A Yousem, Mary Beth Beasley

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