Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Fahd Al-MullaJames J Going

Abstract

A substantial number of patients with early-stage colorectal cancer relapse from metastatic disease. Identification of these patients by genetic profiling of their primary tumours may allow more informed follow-up and tailored administration of adjuvant therapy. Primary tumours from 70 patients with early-stage and largely microsatellite-stable colorectal cancer were profiled using metaphase-based comparative genomic hybridization (CGH) and the aberrations confirmed independently in a subset of patients using microarray-based CGH. Of the 70 cancers, 61 were amenable to CGH, and follow-up data was available from 56 patients. Genomic aberrations were correlated with patients' survival using univariate, multivariate and Kaplan-Meier survival curves. Metastatic primary tumours exhibited more complex genomic aberrations than non-metastatic primary tumours. Loss of chromosome 4p was an independent prognostic factor in early-stage colorectal cancer using multivariate analysis (Hazard ratio, 9.6; 95% CI, 3.3-28; P = 0.0001). Loss of both chromosome arms 8p and 18q had a statistically significant negative effect on disease-free survival. Moreover, primary tumours with loss of both chromosomes 4 and 14q bestowed poorer prognosis than tum...Continue Reading

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Citations

Aug 30, 2007·Diseases of the Colon and Rectum·Najat MourraSylviane Olschwang
Jul 1, 2011·Cellular Oncology (Dordrecht)·R P M BrosensG A Meijer
Aug 13, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Salah A Al-HumoodFahd Al-Mulla
Apr 11, 2012·Polski przeglad chirurgiczny·Bartłomiej Knychalski, Tadeusz Lukieńczuk
Oct 10, 2006·Future Oncology·Danish MazharWolfgang Heller
Oct 1, 2014·International Journal of Molecular Sciences·Rola H AliFahd Al-Mulla
Sep 1, 2007·Expert Opinion on Medical Diagnostics·Jamie Murphy BStephen A Bustin
Jun 27, 2006·Clinical Colorectal Cancer·Amy D'Orazio
Jun 7, 2015·BMC Genomics·Inès J Goossens-BeumerTom van Wezel
Dec 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fahd Al-MullaWalter Kolch
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias KlatteAllan J Pantuck
Jan 30, 2013·Journal of Cellular Physiology·Fahd Al-MullaKam C Yeung
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Devasis ChatterjeeMurray B Resnick

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