PMID: 9536276Apr 16, 1998Paper

Genetic prognostic markers in colorectal cancer

Molecular Pathology : MP
R S Houlston, I P Tomlinson

Abstract

The contribution of molecular genetics to colorectal cancer has been restricted largely to relatively rare inherited tumours and to the detection of germline mutations predisposing to these cancers. However, much is now also known about somatic events leading to colorectal cancer. A number of studies has been undertaken examining possible relations between genetic features and prognostic indices. While many of these studies are small and inconclusive, it is clear that a number of different pathways exist for the development of this cancer and some molecular characteristics correlate with clinicopathological features. With the advent of methods for the rapid genotyping of large numbers of colorectal cancers, it should be possible to evaluate fully the clinical usefulness of colorectal cancer genotypes through multivariate analyses.

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Citations

Oct 7, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R HughesG Jenkins
Apr 16, 2002·Molecular Pathology : MP·I M Frayling
Apr 6, 2011·Future Oncology·Liang ChengAntonio Lopez-Beltran
Jun 26, 2017·Journal of Theoretical Biology·Ehsan Saghapour, Mohammadreza Sehhati
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·M SpinolaT A Dragani
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hussam H MadyMona F Melhem
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Jul 19, 2001·Cancer Investigation·J S Ross, B J McKenna
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Monica SpinolaEmanuela Taioli

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