Genetic radiation risks: a neglected topic in the low dose debate

Environmental Health and Toxicology
Inge Schmitz-FeuerhakeSebastian Pflugbeil

Abstract

To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. The value is based on experiments on mice due to reportedly absent effects in the Japanese atomic bomb (Abomb) survivors. To review the published evidence for heritable effects after ionising radiation exposures particularly, but not restricted to, populations exposed to contamination from the Chernobyl accident and from atmospheric nuclear test fallout. To make a compilation of findings about early deaths, congenital malformations, Down's syndrome, cancer and other genetic effects observed in humans after the exposure of the parents. To also examine more closely the evidence from the Japanese A-bomb epidemiology and discuss its scientific validity. Nearly all types of hereditary defects were found at doses as low as one to 10 mSv. We discuss the clash between the current risk model and these observations on the basis of biological mechanism and assumptions about linear relationships between dose and effect in neonatal and...Continue Reading

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Citations

Jan 25, 2017·International Journal of Health Services : Planning, Administration, Evaluation·Alison Rosamund Katz
Feb 18, 2020·Cancer Investigation·Christopher Busby
May 28, 2019·Frontiers in Genetics·Nadia NarendranOlga Kovalchuk
Jan 29, 2020·Critical Reviews in Oncology/hematology·Louis De CourcyLoredana G Marcu

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