PMID: 16789141Feb 1, 1974Paper

Genetic recombination for antigenic markers of antigenically different strains of influenza B virus

Journal of Virology
K Tobita, E D Kilbourne


Incorporation of trypsin in agar overlay or fluid maintenance media resulted in enhancement of plaquing efficiency and replication of influenza B viruses in primary chicken embryo fibroblasts. Using this improved technique, recombination was attempted with two serologically distinct strains of influenza B virus, B/Lee/40 and B/Massachusetts/1/71. After mixed infection, two virus clones were selected and characterized in detail. Hemagglutination inhibition and neuraminidase inhibition tests showed that these viruses are reciprocal antigenic recombinants with hemagglutinin derived from one parent and neuraminidase from the other. Serological examinations of the antisera to these recombinants confirmed the results. The frequency of recombination was high in the present system and 64% of the virus clones isolated without selection from the mixed yield were recombinants. This high recombination frequency is consistent with the genomic reassortment that is characteristic of recombination of influenza A viruses.


Feb 1, 1968·Journal of Virology·E D KilbourneR G Webster
Jul 1, 1969·The Journal of General Virology·B EasterdayG C Schild
Jan 1, 1971·Archiv für die gesamte Virusforschung·K Tobita
Jun 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·J L Schulman, E D Kilbourne
May 1, 1968·The Journal of General Virology·C K Paniker
Jan 1, 1968·Archiv für die gesamte Virusforschung·P E CameG Shimonaski
Dec 1, 1968·The Journal of General Virology·R G WebsterE D Kilbourne
Oct 1, 1953·The Australian Journal of Experimental Biology and Medical Science·B PERRY, F M BURNET
Aug 1, 1954·The Australian Journal of Experimental Biology and Medical Science·B T PERRYF M BURNET
Jan 1, 1962·Cold Spring Harbor Symposia on Quantitative Biology·G K HIRST
Apr 1, 1955·The Journal of Experimental Medicine·E D KILBOURNE

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Jan 1, 1982·Microbiology and Immunology·M ShibataS Suzuki
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Jan 1, 1975·Archives of Virology·K Tobita, E D Kilbourne
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Nov 1, 1979·Journal of Clinical Microbiology·S Ramia, S A Sattar
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