Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer

Frontiers in Oncology
Aesha I AliClare Y Slaney

Abstract

Conventional treatments for pancreatic cancer are largely ineffective, and the prognosis for the vast majority of patients is poor. Clearly, new treatment options are desperately needed. Immunotherapy offers hope for the development of treatments for pancreatic cancer. A central requirement for the efficacy of this approach is the existence of cancer antigen-specific T cells, but these are often not present or difficult to isolate for most pancreatic tumors. Nevertheless, specific T cells can be generated using genetic modification to express chimeric antigen receptors (CAR), which can enable T cell responses against pancreatic tumor cells. CAR T cells can be produced ex vivo and expanded in vitro for infusion into patients. Remarkable responses have been documented using CAR T cells against several malignancies, including leukemias and lymphomas. Based on these successes, the extension of CAR T cell therapy for pancreatic cancer holds great promise. However, there are a number of challenges that limit the full potential of CAR T cell therapies for pancreatic cancer, including the highly immunosuppressive tumor microenvironment (TME). In this article, we will review the recent progress in using CAR T cells in pancreatic cancer ...Continue Reading

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Garin-ChesaW J Rettig
Feb 13, 1988·British Medical Journal·R C Williamson
Jan 1, 1988·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M NapG J Fleuren
Oct 1, 1993·Human Pathology·Y YamanakaM Korc
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K Chang, I Pastan
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Jan 3, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·F OzawaM W Büchler
Apr 18, 2001·Trends in Cell Biology·E J Brown, W A Frazier
Oct 5, 2001·American Journal of Clinical Oncology·H SafranU Tantravahi
Nov 5, 2002·Nature Biotechnology·Michael H KershawPatrick Hwu
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Sep 2, 2004·Journal of Molecular Histology·G KristiansenP Altevogt
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nobuyoshi HiraokaSetsuo Hirohashi
Nov 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M WinterCharles J Yeo
Feb 7, 2007·Cancer Research·Chenwei LiDiane M Simeone
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hua ZhangCrystal L Mackall
Oct 3, 2007·Cancer Research·Carolyn E ClarkRobert H Vonderheide
Feb 5, 2008·Cancer Research·Rosa F HwangCraig D Logsdon
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carmine CarpenitoCarl H June
Mar 24, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E A te VeldeP J van Diest
Feb 25, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard A MorganSteven A Rosenberg
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Norihisa SaekiXifeng Wu
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Dec 16, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria R ParkhurstSteven A Rosenberg
Mar 12, 2011·Expert Opinion on Therapeutic Targets·Jiang LongMin Li
Aug 17, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Usha L KatariJuan F Vera
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Mar 31, 2012·Current Drug Targets·T TroianiF Ciardiello
Aug 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine FeigDavid A Tuveson
May 2, 2013·Neoplasia : an International Journal for Oncology Research·Xikun ZhouYu-quan Wei

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Citations

Jan 16, 2020·Journal of Clinical Medicine·Daniel Sur AlexandruIrimie
Aug 28, 2020·Journal for Immunotherapy of Cancer·Steven C KatzRichard P Junghans
Mar 7, 2020·Digestive Diseases and Sciences·Jia Wu, Jianting Cai
May 7, 2020·International Journal of Molecular Sciences·Kinga B StopaMonika A Jakubowska
Feb 23, 2020·Frontiers in Immunology·Wenting ZhangHua Jin
Oct 4, 2020·Journal of Hematology & Oncology·Yunzhen QianChen Liu
Sep 19, 2020·Cancer Cell·Adham S BearMark H O'Hara
Nov 1, 2020·Cancers·Clare Y Slaney, Michael H Kershaw
Mar 13, 2021·Cellular Oncology (Dordrecht)·Thomas P BrouwerNoel F C C de Miranda
Jun 3, 2021·International Journal of Molecular Sciences·Aditi Kothari, Matthew J Flick
Sep 4, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aesha I AliClare Y Slaney

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Methods Mentioned

BETA
xenograft
xenografts

Clinical Trials Mentioned

NCT01583686
NCT03323944
NCT02959151
NCT01897415
NCT02159716
NCT02580747
NCT02930993
NCT01355965
NCT02465983
NCT03497819

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