Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.

Arteriosclerosis, Thrombosis, and Vascular Biology
Brian J BennettA J Lusis

Abstract

We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery, a murine model of advanced atherosclerosis. We examined genetic contributions to innominate atherosclerotic plaque size and cellular composition in an intercross between C57BL/6J.Apoe(-/-), a strain susceptible to aortic lesions, and C3H/HeJ.Apoe(-/-), a strain resistant to aortic lesions. Surprisingly, total innominate lesion size was similar in the two strains. Genetic analyses identified one novel locus on Chromosome 2 for innominate artery lesion size, a significant locus for fibrous cap thickness on Chromosome 15, and several suggestive loci for cellular composition, all distinct from loci influencing aortic lesions. The Chromosome 2 locus contains a candidate, CD44. We show that CD44 is expressed in the innominate artery and differs strikingly in expression between the parental strains. Multiple aspects of innominate lesion composition are genetically determined, but in a manner largely independent of the genetic contributions to aortic lesions.

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Citations

Jan 5, 2013·Epidemiology and Infection·E D FosterP M Polgreen
Jun 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diana M ShihAldons J Lusis
Aug 7, 2020·Journal of the Association for Research in Otolaryngology : JARO·Ely Cheikh BoussatyRick Adam Friedman

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