Genetic regulation of hypothalamic cocaine and amphetamine-regulated transcript (CART) in BxD inbred mice

Brain Research
Ericka M BooneSteven J Garlow

Abstract

Cocaine and Amphetamine-Regulated Transcript (CART) peptides are implicated in a wide range of behaviors including in the reinforcing properties of psychostimulants, feeding and energy balance and stress and anxiety responses. We conducted a complex trait analysis to examine natural variation in the regulation of CART transcript abundance (CARTta) in the hypothalamus. CART transcript abundance was measured in total hypothalamic RNA from 26 BxD recombinant inbred (RI) mouse strains and in the C57BL/6 (B6) and DBA/2J (D2) progenitor strains. The strain distribution pattern for CARTta was continuous across the RI panel, which is consistent with this being a quantitative trait. Marker regression and interval mapping revealed significant quantitative trait loci (QTL) on mouse chromosome 4 (around 58.2 cM) and chromosome 11 (between 20-36 cM) that influence CARTta and account for 31% of the between strain variance in this phenotype. There are numerous candidate genes and QTL in these chromosomal regions that may indicate shared genetic regulation between CART expression and other neurobiological processes referable to known actions of this neuropeptide.

References

Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Apr 1, 1994·Genetics·Z B Zeng
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
May 1, 1997·Journal of Chemical Neuroanatomy·P R CouceyroM J Kuhar
Jan 9, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K J Buck, H M Hood
Nov 15, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F ManlyJ M Meer
Jul 16, 2002·Brain Research. Molecular Brain Research·A LakatosM J Kuhar
Jan 10, 2003·Nucleic Acids Research·Judith A BlakeUNKNOWN Mouse Genome Database Group
Jul 12, 2003·Obesity Research·Shumin Zhang, Howard K Gershenfeld
Oct 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jason N JaworskiMichael J Kuhar
Nov 25, 2003·Nature Reviews. Genetics·Oduola AbiolaUNKNOWN Complex Trait Consortium
Jan 28, 2004·Nutritional Neuroscience·Byron C JonesJohn L Beard
Apr 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joao L RochaDaniel Pomp
Jun 23, 2004·Brain Research. Molecular Brain Research·Geraldina Dominguez, Michael J Kuhar
Jun 24, 2004·European Journal of Pharmacology·Shu-Chuan YangHui-Yun Li
Nov 16, 2004·Annals of the New York Academy of Sciences·Geraldina DominguezMichael J Kuhar
Jan 18, 2005·Peptides·A VicenticM J Kuhar
Feb 12, 2005·Endocrinology·Steven J GarlowCharles B Nemeroff
Jun 24, 2005·European Journal of Pharmacology·Richard G HunterMichael J Kuhar
Aug 16, 2005·The Journal of Pharmacology and Experimental Therapeutics·Pastor R CouceyroAnthony W Bannon
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven J GarlowCharles B Nemeroff
Sep 15, 2005·Genetics·Marianna R BevovaGudrun A Brockmann

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Citations

May 18, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Amy F Eisener-DormanLisa M Tarantino
Nov 13, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·John K BelknapTamara J Phillips

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