Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Rong YuanDavid E Harrison

Abstract

Quantitative trait loci (QTL) of longevity identified in human and mouse are significantly colocalized, suggesting that common mechanisms are involved. However, the limited number of strains that have been used in mouse longevity studies undermines the ability to identify longevity genes. We crossed C57BL/6J mice with a new wild-derived strain, Pohn, and identified two life span QTL-Ls1 and Ls2. Interestingly, homologous human longevity QTL colocalize with Ls1. We also defined new QTL for metabolic heat production and body weight. Both phenotypes are significantly correlated with life span. We found that large clone ratio, an in vitro indicator for cellular senescence, is not correlated with life span, suggesting that cell senescence and intrinsic aging are not always associated. Overall, by using Pohn mice, we identified new QTL for longevity-related traits, thus facilitating the exploration of the genetic regulation of aging.

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Citations

Apr 12, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Patrick L HillBrent W Roberts
Sep 8, 2015·Experimental Gerontology·Samantha J AlperJames M Harper
Oct 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Lorna MulveyColin Selman
Jul 10, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Zixuan JiangRobert Pazdro
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Yun-Xia ZhangWang-Wei Cai
Sep 14, 2014·Science China. Life Sciences·LiNa LiuQingPeng Kong
Jul 17, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rebecca L GouldRobert Pazdro

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