Genetic regulation of variable Vi antigen expression in a strain of Citrobacter freundii.

Journal of Bacteriology
N J SnellingsL S Baron

Abstract

Certain strains of the genus Citrobacter exhibit a variable expression of the Vi surface antigen that appears to involve a special mechanism for regulation of gene expression. Two nonlinked chromosomal loci, viaA and viaB, are known to determine nonvariable Vi antigen expression in strains of Salmonella. To confirm the presence of analogous loci in Citrobacter and to ascertain whether either of them is involved in variable Vi antigen expression in this organism, donor strains were constructed from Citrobacter freundii WR7004 and used to transfer their Vi antigen-determining genes to ViaA- and ViaB- Salmonella typhi recipient strains. Vi antigen expression in C. freundii was found to be controlled by loci analogous to the Salmonella via genes. S. typhi recipients of the C. freundii viaA+ genes were restored to the full, continuous expression of the Vi antigen normally seen in S. typhi. Thus, the C. freundii viaA genes appeared to play no role in the variable expression of the Vi antigen. In contrast, S. typhi recipients of the C. freundii viaB+ genes exhibited the rapid, reversible alternation between full Vi antigen expression and markedly reduced Vi antigen expression that was seen to occur in the C. freundii parent. The C. fr...Continue Reading

References

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Citations

Jan 7, 1998·FEMS Microbiology Letters·Y Hashimoto, A Q Khan
Aug 1, 1992·Molecular & General Genetics : MGG·J T OuL S Baron
Nov 22, 2016·Critical Reviews in Microbiology·Xiaomei HuYanguang Cong
May 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kalgi D PandyaKishore R Alugupalli
Aug 23, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J WainG Frankel
May 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sean D ListonChris Whitfield
Jun 1, 1992·Journal of Bacteriology·R K SelanderF A Rubin
Oct 1, 1989·Infection and Immunity·E M DanielsJ B Robbins
Oct 1, 1985·Journal of Clinical Microbiology·F A RubinL S Baron

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