Genetic relatedness of deer mice (Peromyscus maniculatus) infected with Sin Nombre virus

Vector Borne and Zoonotic Diseases
J Jeffrey RootBarry J Beaty

Abstract

The deer mouse (Peromyscus maniculatus) is the primary rodent host of Sin Nombre virus (SNV), the principal etiologic agent of hantavirus pulmonary syndrome in the United States. Many characteristics of SNV infections of deer mice are unknown. To better understand the transmission mechanisms of SNV in deer mice, we conducted mark-recapture sampling and genetic analyses to study deer mouse population density and genetic relatedness from 2001 to 2002. We genotyped each deer mouse at 10 microsatellite loci to estimate relatedness among SNV-infected and SNV-uninfected groups, demographic categories, and individuals. Estimates of average overall population densities ranged from 1.15 to 14.95 deer mice/ha. Estimates of average population densities of SNV-infected deer mice ranged from 0 to 1.55 deer mice/ha. When evaluated as groups at one of two study sites, SNV-infected deer mice were more related to one another, on average, than they were to their uninfected cohorts. Pairwise coefficients of relatedness among individuals indicated that several deer mice infected with SNV were closely related. Most infected mice were males. These results are consistent with the hypothesis that transmission of SNV often is associated with breeding a...Continue Reading

References

Jun 1, 1996·Molecular Ecology·M S BlouinS Lotz
Mar 19, 1999·Emerging Infectious Diseases·K D AbbottJ N Mills
Mar 19, 1999·Emerging Infectious Diseases·C H CalisherB J Beaty
Mar 19, 1999·Emerging Infectious Diseases·R E Shope
Oct 26, 2000·Molecular Ecology·S E ChirhartI F Greenbaum
Aug 16, 2001·The American Journal of Tropical Medicine and Hygiene·R J DouglassJ N Mills

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Citations

Feb 2, 2008·Vector Borne and Zoonotic Diseases·Elisabeth Fichet-CalvetJan ter Meulen
Apr 9, 2010·Clinical Microbiology Reviews·Colleen B JonssonOlli Vapalahti
Oct 8, 2008·Immunological Reviews·Günther SchönrichRainer G Ulrich
Feb 2, 2021·Evolutionary Applications·Kaylee A ByersMichael C Whitlock

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