Genetic relationship between measures of HDL phenotypes and insulin concentrations

Arteriosclerosis, Thrombosis, and Vascular Biology
D L RainwaterS M Haffner

Abstract

We used data from the San Antonio Family Heart Study to determine the HDL correlates of the insulin resistance syndrome (IRS), as reflected by insulin concentrations in nondiabetic subjects. We measured insulin concentrations both in the fasting state and 2 hours after a glucose challenge (2-hour insulin) and we assessed seven aspects of HDL phenotype, including size and concentration of both lipid and protein components. Measurements were obtained from 1202 nondiabetic members of 42 families. Initial quantitative genetic analyses revealed that a substantial portion of phenotypic variation in the nine variables was due to genes (heritabilities, h2, ranged from 0.32 to 0.47). We then conducted a series of bivariate genetic analyses, which indicated that there were significant additive genetic correlations (ie, pleiotropy) between the two measures of insulin and five of seven HDL measures tested, including concentrations of HDL cholesterol (fasting insulin only) and triglyceride, and HDL size distributions of apoAI, apoAII, and cholesterol; concentrations of apoAI and apoAII were not genetically related to either insulin measure. Increased insulin levels were associated with relatively smaller HDL phenotypes, and considering a si...Continue Reading

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References

Apr 1, 1992·Diabetes·M C SchumacherS C Elbein
Jul 1, 1992·Diabetes·B C MartinA S Krolewski
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M LaaksoL Mykkänen
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R R WingK A Matthews
Oct 1, 1988·Metabolism: Clinical and Experimental·A GargP Raskin
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M ModanA Chetrit
Oct 7, 1988·JAMA : the Journal of the American Medical Association·M A AustinR M Krauss
Aug 1, 1986·Journal of Biochemical and Biophysical Methods·M L ChengJ L VandeBerg
Sep 1, 1983·American Journal of Epidemiology·T J OrchardA L Drash
May 1, 1993·American Journal of Epidemiology·M Laakso
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss
Mar 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S M Haffner
Apr 22, 1993·The New England Journal of Medicine·D A HellerG E McClearn
Dec 1, 1995·Atherosclerosis·D L RainwaterT D Dyer
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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Citations

Apr 8, 2006·Current Hypertension Reports·Michèle M SaleBarry I Freedman
Mar 13, 2002·Atherosclerosis·David L RainwaterJohn L VandeBerg
Jun 7, 2005·Postgraduate Medical Journal·G D KolovouD V Cokkinos
Oct 28, 2003·Diabetes·Weihong TangUNKNOWN National Heart, Lung, and Blood Institute Family Heart Study
Apr 19, 2013·Journal of Lipid Research·Genesio M KarereLaura A Cox
Dec 2, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·M Elizabeth TejeroA G Comuzzie
Jun 18, 2017·Journal of Medical Primatology·Michael C MahaneyJohn L VandeBerg
Apr 17, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·P M OkinR B Devereux

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