Genetic relationships between the mutations spade and Sternopleural and the wingless gene in Drosophila development

Developmental Biology
M A BuratovichJ R Whittle

Abstract

In Drosophila melanogaster, there are cases in which gene products contributing to the same developmental event may derive from closely adjacent transcription units and may even share cis-regulatory sequences. Correct recognition of such genomic organization is central to an understanding of developmental mechanisms. The adult phenotypes of combinations between the mutations spade, Sternopleural, and wingless suggest that they are lesions in functionally related genes within the same chromosomal region. wingless mutations fail to complement the recessive mutation spade. The spade mutation, as previously shown, behaves as a lesion in a regulatory site of wingless, sited 5' to the transcription unit, and is concerned with particular postembryonic functions of wingless. While showing wingless-like phenotypes in combination with Sternopleural, even lethal alleles of wingless complement the recessive lethality of Sternopleural alleles. Mutations in Sternopleural increase the severity of wingless phenotypes in many wingless-dependent processes during postembryonic development, and this interaction can occur when the only functional copies of Sp or wg are located in either opposing chromosomes or the same chromosome. This is inconsist...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A KassisN Perrimon
Jul 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J R KnottC E Henry
Jun 26, 1992·Cell·R Nusse, H E Varmus
Apr 19, 1991·Cell·K D Tartof, S Henikoff
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L D Williams, B R Shaw
Dec 1, 1994·Developmental Biology·J Klingensmith, R Nusse
Jan 1, 1994·Journal of Physiology, Paris·M Kessel
Dec 1, 1993·Mechanisms of Development·M C MoroniF Mavilio
Oct 28, 1994·Science·D S Kessler, D A Melton
Apr 1, 1994·Journal of Cellular Biochemistry·D DoeneckeB Drabent
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M F KielmanL F Bernini
Jan 22, 1993·Science·J P CousoA Martínez-Arias
Feb 1, 1993·The Journal of Cell Biology·C T Wu
Feb 26, 1993·Cell·G Struhl, K Basler
Feb 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R T Moon
Apr 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T NakayamaY Takami
Feb 1, 1996·Developmental Biology·P W Holland, J Garcia-Fernàndez
Jun 12, 1996·Molecular & General Genetics : MGG·B C DunkovR Feyereisen
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D WangF J Ayala
Oct 1, 1993·Genome Génome / Conseil National De Recherches Canada·T HankelnE R Schmidt
Jan 1, 1995·Trends in Cardiovascular Medicine·R Bodmer
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·C Nüsslein-VolhardH Kluding
Jan 1, 1988·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Michael Brand, José A Campos-Ortega

❮ Previous
Next ❯

Citations

Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J R MorrisC T Wu
Jan 8, 2015·Fly·Fabian Heinz Jenny, Konrad Basler
Nov 14, 2002·Annual Review of Genetics·Ian W Duncan
Sep 13, 2005·Evolution; International Journal of Organic Evolution·Ian Dworkin
Jan 5, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Silvia Muñoz-DescalzoAlfonso Martinez Arias
Jun 13, 2001·Developmental Biology·K GieselerJ Pradel
Jun 3, 2021·Genes·Samantha C PetersonStacey L Hanlon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.