Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Lindsay C BurrageJoseph H Nadeau

Abstract

Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr(A/J)/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three replicate CSS surveys showed remarkable consistency, with 13 A/J-derived chromosomes reproducibly conferring resistance to high-fat-diet-induced obesity. Twenty CSS intercrosses, one derived from each of the 19 autosomes and chromosome X, were used to determine the number and location of quantitative trait loci (QTLs) on individual chromosomes and localized six QTLs. However, analyses of mean body weight in intercross progeny versus C57BL/6J provided strong evidence that many QTLs discovered in the CSS surveys eluded detection in these CSS intercrosses. Studies of the temporal effects of these QTLs suggest that obesity resistance was dynamic, with QTLs acting at different ages or after different durations of diet exposure. Thus, these studies provide insight into the genetic architecture of complex traits such as resistance to diet-induced obesity in the C57BL/6J-Chr(A/J)/NaJ CSSs. Because some of the QTLs d...Continue Reading

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Citations

Sep 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joseph H NadeauToshihiko Shiroishi
Mar 1, 2013·Thrombosis and Haemostasis·Ilse ScroyenH Roger Lijnen
Aug 16, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Anatole GhazalpourRenée C LeBoeuf
Jul 9, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sabrina H SpiezioRenée C LeBoeuf
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Apr 5, 2019·Journal of Nutrition and Metabolism·Yosra AlhindiAivaras Ratkevicius
Aug 19, 2016·Molecular Cancer Research : MCR·Stephanie K DoernerJoseph H Nadeau

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