PMID: 6161206Jan 1, 1981Paper

Genetic resistance to the induction of experimental allergic encephalomyelitis in Lewis rats. I. Genetic analysis of an apparent mutant strain with phenotypic resistance to experimental allergic encephalomyelitis

The Journal of Experimental Medicine
F J WaxmanJ E Coe

Abstract

Clinical resistance to the induction of experimental allergic encephalomyelitis was observed in a closed colony of Lewis (designated Le-R) rats. Disease susceptibility in randomly bred animals appeared to increase with increasing age. In the small group of young Le-R rats, which were susceptible, disease onset was delayed, severity of symptoms was reduced, and duration of clinical signs was abbreviated compared to conventional Lewis rats. The severity of histologic neural tissue lesions correlated with clinical observations. Breeding experiments indicated that most Le-R rats were resistant to disease induction regardless of whether their ancestors had been selected for susceptibility or resistance. The F3 generation of resistant lineage was uniformly resistant at all ages tested. Virtually all (Lewis X Le-R)F1 rats of either sex were resistant when challenged at 7-8 wk of age indicating that resistance was a dominant autosomal trait. Approximately half of (F1 X Lewis) backcross rats developed paralytic EAE whereas one-fourth were entirely resistant, suggesting that disease resistance may be mediated by one or two genes. Le-R rats shared at least some of the Lewis rat major histocompatibility antigens. Resistance apparently did ...Continue Reading

References

Jan 1, 1977·Journal of Neurochemistry·C H ChouR F Kibler
Nov 1, 1977·The Journal of Experimental Medicine·R F KiblerD E McFarlin
Sep 1, 1977·European Journal of Immunology·D H AddaR Depieds
Apr 1, 1974·Cellular Immunology·A A Vandenbark, D J Hinrichs

❮ Previous
Next ❯

Citations

Oct 23, 2013·PloS One·Laura Mellado RaneaSaleh M Ibrahim
Aug 30, 2014·PloS One·Sydney K ElizerDaniel J Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
J E Swierkosz, R H Swanborg
The Journal of Immunology : Official Journal of the American Association of Immunologists
Z LandoR Arnon
© 2021 Meta ULC. All rights reserved