Genetic risk and age in Parkinson's disease: Continuum not stratum.

Movement Disorders : Official Journal of the Movement Disorder Society
Mike A NallsInternational Parkinson's Disease Genomics Consortium (IPDGC)

Abstract

Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset. Genetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset. Increasing genetic risk scores were associated with earlier age at onset (beta = -0.10, P = 2.92 × 10(-8) , adjusted r(2)  = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO). Common genetic risk factors have a small but consistent association with AAO in PD.

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Citations

Apr 25, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Meike Kasten, Christine Klein
Jul 13, 2016·Human Molecular Genetics·Erin M Hill-BurnsHaydeh Payami
Apr 1, 2017·Molecular Genetics & Genomic Medicine·Melinda BarkhuizenAnne F Grobler
Feb 9, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Lasse PihlstrømMathias Toft
Aug 23, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Stefanie LercheKathrin Brockmann
Jan 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sara Bandres-CigaAndrew B Singleton
Apr 9, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Cornelis BlauwendraatUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)
Nov 23, 2019·Brain : a Journal of Neurology·Cornelis BlauwendraatAndrew B Singleton
Dec 10, 2019·Journal of Parkinson's Disease·UNKNOWN International Parkinson Disease Genomics Consortium (IPDGC)
Jan 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Hirotaka IwakiAndrew B Singleton
Aug 14, 2019·Neurology. Genetics·Hirotaka IwakiMike A Nalls
Dec 1, 2019·Journal of Medical Genetics·Hampton LeonardUNKNOWN International Parkinson's Disease Genomic Consortium (IPDGC)
Aug 4, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Lasse Pihlstrøm, Mathias Toft
Dec 25, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Frédéric MoisanAlexis Elbaz
Sep 10, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·J A ObesoA J Stoessl
May 28, 2019·NPJ Parkinson's Disease·Kimberley J BillingsleySulev Koks
Feb 12, 2017·European Journal of Epidemiology·Sofiane KabAlexis Elbaz
Nov 30, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Madeleine KristiansenLasse Pihlstrøm
Dec 26, 2018·Journal of Parkinson's Disease·Honglei Chen, Beate Ritz
Oct 20, 2018·Neurology. Genetics·Zachary D WallenHaydeh Payami
Mar 27, 2020·Nature Reviews. Neurology·Anthony H V Schapira, Huw R Morris
Mar 15, 2018·Cell and Tissue Research·K J BillingsleyA B Singleton
Oct 6, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Sophie FenglerElke Kalbe
Mar 30, 2019·Trends in Genetics : TIG·Danai ChasiotiAndrew J Saykin
Apr 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Chunyu LiHuifang Shang
Apr 20, 2021·Frontiers in Neuroscience·Bin LiJinchen Li
May 14, 2021·Frontiers in Neuroscience·Bin LiJinchen Li
May 15, 2021·Neurology. Genetics·Isabel Alfradique-DunhamJoshua M Shulman
Oct 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Lasse PihlstrømOle A Andreassen

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