PMID: 9546236Apr 18, 1998Paper

Genetic risk factor for abdominal aortic aneurysm: HLA-DR2(15), a Japanese study

Journal of Vascular Surgery
H HiroseM D Tilson

Abstract

Autoimmunity has been proposed to play a role in the pathogenesis of the abdominal aortic aneurysm (AAA). Several autoimmune diseases are associated with specific HLA DR alleles. These experiments were carried out to determine whether the same HLA DR types that have been reported to be associated with AAA in a mixed North American population are similarly associated with AAA in a more homogeneous group of patients in Japan. HLA DR typing was performed by a serologic method on samples of peripheral blood of patients with nonspecific infrarenal AAA in Nagasaki University Hospital in Japan. The frequencies of HLA DR antigens were compared with those of volunteers approximately matched for age and sex from the same referral area. HLA DR haplotypes were determined in 46 Japanese patients with AAA and in 50 patients in a control group. The HLA-DR2(15) antigen was observed in 27 (58.7%) patients (29 alleles 31.5%) with AAA and in 14 (28%) subjects (16 alleles 26.0%) in the control group (p < 0.005). The data suggest that HLA-DR2(15) has an important role as a genetic risk factor for AAA in Japanese patients, as previously reported in a mixed North American population.

Citations

Dec 22, 2006·Annals of the New York Academy of Sciences·Christina DuftnerMichael Schirmer
Dec 22, 2006·Annals of the New York Academy of Sciences·Chris D PlatsoucasJohn V White
Jan 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kari HemminkiJan Sundquist
Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Tiffany W ChangDavid S Wilkes
Jan 25, 2002·Annals of the New York Academy of Sciences·H Hirose, M D Tilson
Aug 20, 2009·Cardiology in Review·Konstantinos D RizasMartin D Tilson
Jan 16, 2008·Circulation·Helena KuivaniemiM David Tilson
Jun 9, 2019·BMC Medical Genetics·Javier E Anaya-AyalaCarlos A Hinojosa
Jun 23, 2010·Angiology·Athanasios SaratzisGeorge D Kitas
Oct 23, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C J van Vlijmen-van KeulenJ A Rauwerda
Jun 12, 2003·The International Journal of Biochemistry & Cell Biology·Baiping ZhangIan N M Day
Dec 15, 2010·Annals of Vascular Surgery·Irene HinterseherHelena Kuivaniemi

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