PMID: 9192947Jun 1, 1997Paper

Genetic risk factors for chronic obstructive pulmonary disease

The European Respiratory Journal
A J SandfordP D Paré

Abstract

Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only a minority of cigarette smokers develop symptomatic disease. Studies of families and twins suggest that genetic factors also contribute to the development of COPD. We present a detailed literature review of the genes which have been investigated as potential risk factors for this disease. The only established genetic risk factor for COPD is homozygosity for the Z allele of the alpha1-antitrypsin gene. Heterozygotes for the Z allele may also be at increased risk. Other mutations affecting the structure of alpha1-antitrypsin or the regulation of gene expression have been identified as risk factors. Genes, including those for alpha1-antichymotrypsin, alpha2-macroglobulin, vitamin D-binding protein and blood group antigens, have also been associated with the development of COPD. Variants of the cystic fibrosis transmembrane regulator gene have been identified as risk factors for disseminated bronchiectasis. The genetic basis to chronic obstructive pulmonary disease has begun to be elucidated and it is likely that several genes will be implicated in the pathogenesis of this disease. The knowledge gained from such studies may al...Continue Reading

Citations

Nov 2, 2004·Der Internist·M Pfeifer
Mar 5, 2004·Patient Education and Counseling·Paul van der ValkCees van Herwaarden
Jul 1, 2004·Archivos de bronconeumología·M Miravitlles, UNKNOWN Grupo de trabajo de la Asociación Latinoamericana del Tórax (ALAT)
Nov 18, 2011·Mucosal Immunology·S KeelyP M Hansbro
Jul 27, 2000·The New England Journal of Medicine·P J Barnes
Jul 26, 2008·Genetic Testing·Marija StankovicDragica Radojkovic
May 17, 2000·Current Opinion in Pulmonary Medicine·J C Chen, D M Mannino
Feb 15, 2002·Current Opinion in Pulmonary Medicine·Andrew J SandfordPeter D Paré
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·D SchellenbergA J Sandford
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·R M Senior, N R Anthonisen
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·A J SandfordP D Paré
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·W Macnee, I Rahman
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·E CavarraG Lungarella
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·S C McCloskeyD A Lomas
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Oscar JoostDaniel J Gottlieb
Mar 15, 2003·American Journal of Respiratory and Critical Care Medicine·Jemma B WilkRichard H Myers
Jan 11, 2005·American Journal of Respiratory and Critical Care Medicine·Claudia ReinhardHolger Schulz
Dec 15, 2007·Reviews on Environmental Health·Lesley Rushton
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Thomas L Petty
Jul 1, 2005·Treatments in Respiratory Medicine·Irfan Rahman
Oct 27, 2011·Journal of Atherosclerosis and Thrombosis·Hiromichi WadaKoji Hasegawa
Feb 7, 2002·Biochemical and Biophysical Research Communications·Ikumi MatsushitaNaoto Keicho
Dec 18, 2010·Expert Review of Clinical Immunology·Begoña CasadoPaolo Iadarola
Oct 22, 2008·Expert Review of Proteomics·Begona CasadoMartin Kussmann
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Maurizio Moretti
Jul 5, 2005·Expert Opinion on Investigational Drugs·H J Dyke, J G Montana
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S V Culpitt, D F Rogers
Jul 16, 2005·Experimental Lung Research·Subhadeep Chakrabarti, Kamala D Patel
Jun 10, 2000·Chest·W MacNee

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