Genetic risk factors for eating disorders: an update and insights into pathophysiology

Therapeutic Advances in Psychopharmacology
Hubertus HimmerichJanet Treasure

Abstract

Genome-wide-association studies (GWASs), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and binge-eating disorder are relatively scarce, with the exception of a few formal genetic and small-sized candidate-gene-association studies. In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.

References

Jan 1, 1977·Annual Review of Microbiology·D C Savage
Feb 1, 1986·Neurochemical Research·L R Hegstrand, R J Hine
Oct 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·A J HollandA H Crisp
Jan 1, 1994·The International Journal of Eating Disorders·M P LevineL D Hessen
Jul 26, 1996·American Journal of Medical Genetics·M M Weber
Jun 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·T Weissensteiner, J S Lanchbury
Jan 16, 1998·The International Journal of Eating Disorders·P Hay, C Fairburn
Dec 11, 1999·The International Journal of Eating Disorders·C M BulikK S Kendler
Mar 24, 2000·Journal of Clinical Epidemiology·A Thornton, P Lee
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Aug 10, 2000·Journal of Child and Adolescent Psychopharmacology·M S Sokol
Jan 13, 2001·Zeitschrift für Rheumatologie·H O Besedovsky, A del Rey
Mar 23, 2001·The International Journal of Eating Disorders·M StroberW Kaye
May 5, 2001·Trends in Microbiology·D A Relman, S Falkow
Aug 10, 2001·Psychiatry·M N Miller, A J Pumariega
Jan 19, 2002·American Journal of Human Genetics·D E GriceW H Berrettini
Mar 26, 2002·Human Molecular Genetics·Bernie DevlinWalter H Kaye
Dec 12, 2002·American Journal of Human Genetics·Cynthia M BulikWalter H Kaye
Dec 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sergueï O FetissovTomas Hökfelt
Oct 25, 2003·Psychoneuroendocrinology·Kai G KahlMartin H Schmidt
Dec 31, 2003·Molecular Psychiatry·M NilssonK Dahlman-Wright
Aug 4, 2004·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Anke HinneyJohannes Hebebrand
Oct 13, 2004·The International Journal of Eating Disorders·Ted Reichborn-KjennerudJennifer R Harris
Nov 4, 2004·European Journal of Human Genetics : EJHG·Ruth Elizabeth Urwin, Kenneth Patrick Nunn
Mar 12, 2005·Science·Robert J KleinJosephine Hoh
Apr 1, 2005·The American Journal of Psychiatry·Federica TozziWalter H Kaye
Apr 2, 2005·Viral Immunology·Marni N SilvermanAndrew H Miller
Apr 9, 2005·Annals of the New York Academy of Sciences·Essi Viding
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David M MutchGary Williamson
Oct 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sergueï O FetissovTomas Hökfelt
Oct 27, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Palmiero MonteleoneMario Maj

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Citations

Jul 18, 2019·Eating and Weight Disorders : EWD·Enrica MarzolaWalter H Kaye
Jul 24, 2020·The Nurse Practitioner·Evgenia Komar, Brayden Kameg
Sep 4, 2020·International Journal of Molecular Sciences·Olivia PatsalosHubertus Himmerich
May 8, 2020·Journal of Clinical Medicine·Howard Steiger, Linda Booij
May 1, 2020·Frontiers in Pharmacology·Olivia PatsalosHubertus Himmerich
Apr 30, 2020·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Zaida AgüeraFernando Fernández-Aranda
Dec 8, 2020·Clinical Psychology & Psychotherapy·Alessio Maria MonteleoneEnrica Marzola
Jan 30, 2021·Endocrine Research·Areti AugouleaIrene Lambrinoudaki
Feb 12, 2021·Frontiers in Psychiatry·Hubertus HimmerichUte Krügel
Feb 2, 2021·Frontiers in Psychiatry·Lukas BergnerHolger Steinberg
Mar 13, 2021·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Jose C Appolinario, Phillipa Hay
May 6, 2021·European Eating Disorders Review : the Journal of the Eating Disorders Association·Jan Alexander de VosGerben J Westerhof
Sep 12, 2020·The International Journal of Eating Disorders·Hui-Wen YehNian-Sheng Tzeng
Jul 31, 2021·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Raphael HirtzAnke Hinney
Aug 28, 2021·Journal of Personalized Medicine·Johanna Louise KeelerBethan Dalton
Oct 8, 2021·Der Nervenarzt·Manfred M Fichter, Norbert Quadflieg
Nov 26, 2021·Eating and Weight Disorders : EWD·Maria Rachele CeccariniMatteo Bertelli
Dec 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johanna Louise KeelerHubertus Himmerich
Jan 11, 2022·Nutrición hospitalaria·Vanesa Erica AngerMónica Teresa Katz
Jan 12, 2022·Eating and Weight Disorders : EWD·Aurore Malet-KarasEric Bertin

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